Abstract
Forty-five male patients suffering from chronic fluorine poisoning and fifteen normal men were investigated. The urinary excretion of oestrone, oestradiol-17?, oestriol and 16-epioestriol was studied. The results revealed a high content of oestrogens in urine. This is explained by a metabolic disorder in the liver.
-
-
Fluoride Induced Down-regulation of IKBKG Gene Expression Inhibits Hepatocytes Senescence.
Background Accumulating evidences have confirmed that liver is one of the more severely damaged organs during chronic fluorosis. However, the detail mechanism is unclear to data. At present, the objective of this study was to investigate the relationship between down-regulation of IKBKG gene expression and hepatocyte senescence induced by sodium fluoride
-
Hepatotoxicity resulting from fluoride consumption in albino holtzman rats
Objectives: To evaluate the eff ect of sustained fluoride consumption on the structure and function of the liver, albino Holtzman rats. Materials and methods: Experimental, prospective, comparative, consisting of 40 female rats two months of age with an average weight of 200 grams, were randomly divided into 4 equal groups: one
-
Sodium fluoride causes oxidative stress and apoptosis in the mouse liver.
The current study was conducted to investigate the effect of sodium fluoride (NaF) on the oxidative stress and apoptosis as well as their relationship in the mouse liver by using methods of flow cytometry, quantitative real-time polymerase chain reaction (qRT-PCR), western blot, biochemistry and experimental pathology. 240 four-week-old ICR mice
-
Strong acute toxicity, severe hepatic damage, renal injury and abnormal serum electrolytes after intravenous administration of cadmium fluoride in rats
Cadmium fluoride (CdF) is commonly used as an insulator for ulta high speed mass telecommunications equipment, and there is a considerable risk that industrial workers will inhale CdF particles. Despite the possibility that acute exposure can cause harmful systemic effects, there are no studies to date that address the health
-
Exocyclic DNA adducts in sheep with skeletal fluorosis resident in the proximity to the Portoscuso-Portovesme industrial estate on Sardinia Island, Italy
The mechanisms by which fluoride produces its toxic effects are still not clear. Therefore, we conducted a cross-sectional study to evaluate the fluoride-induced toxicity on randomly selected sheep with skeletal fluorosis resident near the large non-ferrous metallurgy Portoscuso-Portovesme industrial estate and the Carbonia and Gonnessa towns (control district) in respect
Related Studies :
-