Forty-five male patients suffering from chronic fluorine poisoning and fifteen normal men were investigated. The urinary excretion of oestrone, oestradiol-17?, oestriol and 16-epioestriol was studied. The results revealed a high content of oestrogens in urine. This is explained by a metabolic disorder in the liver.
Liver proteome of mice with different genetic susceptibilities to the effects of fluoride
OBJECTIVE: In this study, we investigated the differential pattern of protein expression in the liver of these mice to provide insights on why they have different responses to F. MATERIAL AND METHODS: Weanling male A/J and 129P3/J mice (n=10 from each strain) were pared and housed in metabolic cages with ad
Dose–effect relationship between drinking water fluoride levels and damage to liver and kidney functions in children.
Although a dose-effect relationship between water fluoride levels and damage to liver and kidney functions in animals has been reported, it was not demonstrated in humans. To evaluate the effects of drinking water fluoride levels on the liver and kidney functions in children with and without dental fluorosis, we identified
Tamarind seed coat extract restores fluoride-induced hematological and biochemical alterations in rats.
Fluoride (F-) is becoming an ineluctable environmental pollutant causing deleterious effects in humans. In the present study, we examined whether tamarind seed coat extract (TSCE) is beneficial against the F--induced systemic toxicity and hematological changes. Wistar rats were randomly grouped as follows: group I served as control; group II intoxicated
The influence of fluoride on the content of testosterone and cholesterol in rat
Fifty four Wistar male rats were randomly divided into three groups, drinking water containing 0.6 mg/L (control group), 100 mg/L, and 200 mg/L sodium fluoride, respectively. Rats were killed at the second, fourth and sixth weeks after experiment initiation, respectively. The levels of serum testosterone, testis cholesterol, and hepatic tissue
Influence of NaF and Na2PO3F(MFP) on glucose metabolism in rat hepatocytes.
Addition of NaF or MFP to rat hepatocytes resulted in a decrease in lactate and in an increase in glucose, 3 and 2-phosphoglycerate production. When dihydroxyacetone was present in the incubation medium both NaF and MFP increased the production of glucose, fructose-1,6-diphosphate, 3 and 2 phosphoglycerate, with a decrease in
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