The oestrone loading test was carried out on fifteen patients suffering from fluorine liver damage. Three pattern curves of the oestrogen fraction (oestrone, 17?-oestradiol and oestriol) excretion in the urine were established. Our data show that there were disturbances in oestrogen metabolism in patients with fluorine liver damage.
Metabolism of steroids in fluorosis. 1. Oestrogens in male urine
Forty-five male patients suffering from chronic fluorine poisoning and fifteen normal men were investigated. The urinary excretion of oestrone, oestradiol-17?, oestriol and 16-epioestriol was studied. The results revealed a high content of oestrogens in urine. This is explained by a metabolic disorder in the liver.
Oxidative stress induced by fluoride in adult mice and their suckling pups.
To assess renal and liver damages in pregnant and lactating mice as well as in their suckling pups, Wistar female mice were given 500 ppm NaF (226 ppm F-) in drinking water from the 15th day of pregnancy until day 14 after delivery. All mice were sacrificed on day 14
[Hydrofluoric acid injury analysis on the health of workers].
Objective: To analyze the damage caused by hydrofluoric acid to the health of operating workers and to explore health monitoring indicators. Method: Occupational health examinations were carried out on 536 hydrofluoric acid operating workers from the etching process at a certain factory, and 256 persons in the control group. Results: Among the
Investigations of soft tissue functions in fluorotic individuals of North Gujurat
The present study was undertaken to investigate the various health problems caused by water-borne fluoride in endemic villages of Mehsana and Banaskantha districts of Gujarat. The study revealed high levels of fluoride in serum samples of the villagers. Mottling of teeth and skeletal complications were common. Intake of fluoride caused
Sodium Fluoride (NaF) Induces Inflammatory Responses Via Activating MAPKs/NF-kB Signaling Pathway and Reducing Anti-inflammatory Cytokine Expression in the Mouse Liver.
At present, no reports are focused on fluoride-induced hepatic inflammatory responses in human beings and animals. This study aimed to investigate the mRNA and protein levels of inflammatory cytokines and signaling molecules for evaluating the effect of different doses (0, 12, 24, and 48 mg/kg) of sodium fluoride (NaF) on inflammatory
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