The oestrone loading test was carried out on fifteen patients suffering from fluorine liver damage. Three pattern curves of the oestrogen fraction (oestrone, 17?-oestradiol and oestriol) excretion in the urine were established. Our data show that there were disturbances in oestrogen metabolism in patients with fluorine liver damage.
Liver damage in chronic fluoride intoxication
Cases of chronic fluoride intoxication due to industrial hazards are rarely reported in the medical literature. The following brief case report of chronic fluoride poisoning is of special interest because of liver involvement, a rarely described feature of the disease. It was presented to the editor in a letter by
Investigations of soft tissue functions in fluorotic individuals of North Gujurat
The present study was undertaken to investigate the various health problems caused by water-borne fluoride in endemic villages of Mehsana and Banaskantha districts of Gujarat. The study revealed high levels of fluoride in serum samples of the villagers. Mottling of teeth and skeletal complications were common. Intake of fluoride caused
Safety of osteoporosis treatment with sodium fluoride, calcium phosphate and vitamin D.
During an 8-year period, 163 consecutive patients with spinal crush fracture osteoporosis started a 5-year treatment with a combination of sodium fluoride (60 mg/day), calcium phosphate (45 mmol/day) and vitamin D2 (18,000 IU/day), and were followed in the outpatient clinic every 3 months. Fourty-three patients completed the 5-year treatment. Mean
Amelioration of the Protein Expression of Cox2, NFkB, and STAT-3 by Some Antioxidants in the Liver of Sodium Fluoride-Intoxicated Rats.
The present study aimed to explore the efficiency of N-acetyl cysteine (NACC) or thymoquinone (TMQ) alone or in combination in the downregulation of inflammatory molecule expression and decreasing hepatic injury in response to sodium fluoride (SF). Sodium fluoride upregulated serum alanine and aspartate transferases activities, tumor necrosis factor ? and
Protective effect of thymoquinone on sodium fluoride-induced hepatotoxicity and oxidative stress in rats
Many active ingredients extracted from herbal and medicinal plants are extensively studied for their beneficial effects. Antioxidant activity and free radical scavenging properties of thymoquinone (TQ) have been reported. The present study evaluated the possible protective effects of TQ against the toxicity and oxidative stress of sodium fluoride (NaF) in
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