Abstract

Five groups of SD male rats were provided with deionized drinking water containing 0 and 150mg/ L NaF, and containing both 150mg/ L NaF and 0. 5, 2. 0 or 4. 0mg / L Na2SeO3 respectively for 10 weeks, in order to observe the effects of different concentrations of selenite in drinking water on the urinary excretion of fluoride and renal damages induced by 150mg/ L NaF, and find out the optimal level of selenite in drinking water against fluoride toxicity. The results showed that fluoride could cause the significant elevation of fluoride ion levels in serum and urine of rats exposed to fluoride in drinking w ater and the obvious renal damages in pathology, enzyme histochemistry and ultrastructure. 2. 0mg / L Na2SeO3 in drinking water induced the most obvious acceleration of fluoride excretion in urine and possessed the most significant antagonistic effects on the renal impairments induced by 150mg / L NaF, those of 0. 5mg/ L Na2SeO3 were not evident, whereas 4.0 mg / L Na2SeO3 appeared to be toxic to kidney. Thus it is concluded that 2.0 mg/ L Na2SeO3 is the optimal concentration for the antagonistic effect on renal impairments induced by 150mg/ L NaF in drinking water .

• Related Studies :

  • Role of fluoride in formation of urinary calculi: studies in rats

    The effect of fluoride on urinary calculi formation in young rats was investigated. Two studies, in which rats received diets that included either higher calcium (9 g/kg diet) or normal calcium (5 g/kg diet), were conducted At each level of calcium, one group of rats received a high level of

  • Medical aspects of excessive fluoride in a water supply

    A 10-year study of 116 persons in Bartlett and 121 in Cameron, Tex., was conducted to determine if prolonged exposure to fluoride in the water supply of Bartlett had produced detectable physiological effects. Bartlett's water contained about 8 p.p.m. F until 1952, when an experimental defluoridation unit was installed, reducing the

  • Subchronic neurotoxicity in rats of the structural fumigant, sulfuryl fluoride

    Inhalation exposure of male and female Fischer 344 rats to sulfuryl fluoride [Vikane (Dow Chemical Company) gas fumigant] at 300 ppm for 6 hr/day, 5 days week, for 13 weeks caused diminished weight gain, dental fluorosis, a slight decrease in grooming, decreased flicker fusion threshold, slowing of flash, auditory and

  • Changes in urinary ion excretion and related renal enzyme activities in fluoride-treated rats

    Fluoride (NaF, 50 mg/kg po) administration to rats caused an increased urinary excretion of inorganic phosphate, calcium, magnesium, potassium, and sodium associated with polyuria. The renal enzyme activities of Na+ and K+-stimulated adenosine triphosphatase [(Na+ + K+)-ATPase], Mg2+ and Ca2+-stimulated adenosine triphosphatase [(Mg2+ + Ca2+)-ATPase], acid phosphatase, and alkaline phosphatase

  • Hemodialyzability of ionizable fluoride in hemodialysis session

    The fluoride ion content in serum and in dialysate medium was determined by means of a fluoride ion-selective electrode in 29 patients undergoing hemodialysis treatment. Abnormally high serum fluoride of 65.9 +/- 28.3 microg l(-1) at the beginning and 46.5 +/- 26.7 microg l(-1) at the completion of the hemodialysis