Abstract

In the search for a simple method of assessing the therapeutic efficacy of sodium fluoride, a prospective study of vertebral radiography during such treatment was carried out. Treatment of osteoporosis with sodium fluoride, calcium and vitamin D was found to enhance the vertical markings of the vertebral trabecular pattern in 69% of patients. This response was graded 1 (failure), 2 (good) and 3 (excellent); Grade 2 or 3 was attained after a mean treatment period of 31.7 months. Subsequent analysis of the vertebral fracture rate revealed that new vertebral fractures had occurred only in patients with Grade 1 and not in those with Grade 2 or 3. We recommend that treatment should aim at increasing the vertebral trabecular pattern to Grade 2 or 3 and that the duration of therapy should be approximately 30 months.

• Related Studies :

  • Skeletal fluorosis in relation to drinking water, nutritional status and living habits in rural areas of Maharashtra, India

    The present study was carried out during May 2010 to December 2011 in three villages which were randomly selected from Warora tehsil of Chandrapur district which is one of the endemic district of Maharashtra. . . . All the presently available ground water samples were collected and the mean fluoride concentration

  • Fluoride-induced changes in 60 retired aluminum workers

    Orthopedic, radiological and analytical examinations were performed in a group of 60 retired disabled workers of an aluminum factory. Occupational disease had previously been recognized in this group because of disturbances in the respiratory and circulatory systems. The age of those examined averaged 49.6 years; the duration of exposure averaged

  • Studies on sural nerve biopsies in endemic skeletal fluorosis

    Sural nerve biopsies from 13 patients with radiologically confirmed skeletal fluorosis were studied for myelinated fibre densities, frequency distribution oftheir diameters, and single teased nerve fibre preparations. It was observed that most of the biopsies showed a marked reduction in myelinated fibre densities with more than half of them in:volving

  • Chronic fluorine intoxication from drinking water

    Summary The case of ? 35-year-old woman is described presenting stiffness and severe pain in the spine, gastric disturbances, stomatitis, paresthesias in legs and arms, especially in the u1nar nerve area, loss of mental acuity, visual disturbances and extreme general malaise. On1y ? few clear-cut objective findings were noted, namely: decreased muscular

  • Effect of fluoride on osteocyte-driven osteoclastic differentiation.

    Highlights Osteocytes can tolerate the toxic dose of fluoride, and PTH [Parathyroid hormone] administration significantly reduced osteocytes viability. PTH aggravated effect of fluoride on osteoclastogenesis related molecules in osteocytes. PTH administration hardly amplified the stimulating effect of fluoride on osteoclastogenesis. The impact of fluoride on osteocyte-driven osteoclast differentiation was stronger

• Related FAN Content :

  • Fluoride & Osteoarthritis

    While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.

  • Skeletal Fluorosis: The Misdiagnosis Problem

    It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.

  • "Pre-Skeletal" Fluorosis

    As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.