Abstract

Objective: Explore the active mechanisms of growth inhibitors (somatostatin, SS) participating in learning and memory obstacles from brick tea fluoride and aluminum poisoning of rats. Method: Based on the tea-drinking habits of herders, a rat chronic brick tea fluoride and aluminum poisoning animal model was established, and randomly divided into control groups and model groups. After the model was established for one year, an eight-arm maze test was performed to observe the differences in the spatial learning and memory capabilities of the two rat groups, and immunochemistry was used to test the changes in the rat hippocampus growth inhibitor expression one year after the model was established.  Results: Compared with the control group, there was a significant difference (P<0.01) in the rat eight-arm maze learning and memory capabilities one year after the model was established, and the rat hippocampus SS expression fell (P<0.01) one year after the model was established. Conclusion: Brick tea fluoride and aluminum poisoning of rats obstructs learning and memory and brain tissue SS expression decreases.

(Translated by Alta Language Services in February 2014, courtesy of Fluoride Action Network)

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