Abstract
Objective: Explore the brain mechanism of the effect of fluorosis on learning and memory behavior. Method: A method combining behavioral observation and biochemical testing was used to study the effects of long-term drinking different concentrations of sodium fluoride on mouse learning and memory behavior and changes in content of brain superoxide dismutase (SOD) and malondialdehyde (MDA). Results: Comparison with the control group: (1) there was a significant decrease (P<0.01) in the number of movements within 3 minutes for the high-fluoride group of mice, and there was trend of uniform change in some other open field behavioral indices of the middle- and high-fluoride groups; (2) there was significant (P<0.05) harm to the learning capabilities of the middle- and high-fluoride groups of mice, but there was no significant change in their memory; (3) the brain SOD activity of the middle-fluoride group of mice was less than that of the control group (P<0.01), while there was no significant effect on the brain MDA content of the high-fluoride group of mice. Conclusion: Fluorosis of mice caused significant harm to some open field behavior and learning capabilities of mice, there was a certain effect on brain SOD activity, and this effect may have a certain relation to the fluoride concentration.
(Translated by Alta Language Services in February 2014, courtesy of Fluoride Action Network)
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The effect of fluorine exposure of pregnant rats on the learning and memory capabilities of baby rats
Objective: Explore the effect and possible mechanisms of fluorine exposure of pregnant rats passing through placental barriers on the learning and memory capabilities of baby rats. Method: Open field behavior and a water maze test were used to observe the effects on the spontaneous behavior and learning and memory on baby
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Neuroprotective influence of taurine on fluoride-induced biochemical and behavioral deficits in rats
Epidemiological and experimental studies have demonstrated that excessive exposure to fluoride induced neurodevelopmental toxicity both in humans and animals. Taurine is a free intracellular B-amino acid with antioxidant and neuroprotective properties. The present study investigated the neuroprotective mechanism of taurine by evaluating the biochemical and behavioral characteristics in rats exposed
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Evaluation of standardized Bacopa monniera extract in sodium fluoride-induced behavioural, biochemical, and histopathological alterations in mice
Effect of standardized Bacopa monniera (BM; family: Scrophulariaceae) extract (100 and 300 mg/kg) against sodium fluoride (NaF; 100 and 200 ppm)-induced behavioural, biochemical, and neuropathological alterations in mice was evaluated. Akinesia, rotarod (motor coordination), forced swim test (depression), open field test (anxiety), transfer latency (memory), cholinesterase (ChE), and oxidative stress
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Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride.
Highlights Sodium fluoride exposure from pregnancy to lactation induces thyroid toxicity. This can affect neurodevelopment and induce behavioural changes. Spirulina platensis role in reversing fluoride-induced toxicity was ascertained. Significant protection was exerted by Spirulina The study investigated the role of Spirulina platensis in reversing sodium fluoride-induced thyroid, neurodevelopment and oxidative alterations
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Integrated transcriptomic and proteomic analysis indicated that neurotoxicity of rats with chronic fluorosis may be in mechanism involved in the changed cholinergic pathway and oxidative stress.
Highlights Chronic fluorosis decreased learning and memory of rats and induced neurotoxicity. Thirteen corresponding DEGs and DAPs (cor-DEGs-DAPs) were identified. Most of cor-DEGs-DAPs were related to neurodegenerative changes and oxidative stress response The neurotoxicity by high fluoride involved in the changes in cholinergic pathway and oxidative stress. Background To reveal the
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Nutrient Deficiencies Enhance Fluoride Toxicity
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Fluoride & IQ: 67 Studies
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Fluoride & Oxidative Stress
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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Fluoride's Direct Effects on Brain: Animal Studies
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