Abstract
Objective: Explore the effect of different doses of chronic exposure of fluoride on rat learning and memory behavior. Method: Selected 46 Wistar rats, randomly divided them into a control group, low-fluoride group, and high-fluoride group, had them respectively drink tap water (control group), 100 mg/L (low-fluoride group), and 200 mg/L (high-fluoride group) sodium fluoride solutions, then five months later used a Y-maze test to observe the effect of chronic fluorosis on the learning and memory behavior of the rats. Results: Compared to the number of times required for the control group to learn the Y-maze test (58.83 +/- 25.12), there was a significant increase (P<0.05) in the number of times required by the low-fluoride group (73.95 +/- 9.77) and high-fluoride group (77.37 +/- 8.69) to learn it, and although the number of times required to learn it increased with the fluoride exposure dose, it was not statistically significant (P>0.05). Conclusion: The results indicate that chronic fluorosis has a significant effect on rat learning and memory behavior.
(Translated by Alta Language Services in February 2014, courtesy of Fluoride Action Network)
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Exposure to environmental neurotoxic substances and neurodevelopment in children from Latin America and the Caribbean.
Environmental (and occupational) exposure to neurotoxic substances is a worldwide problem that can affect children's neurodevelopment (ND). In Latin American and Caribbean (LAC) countries there are over 300 million children living under the threat of neurodevelopmental delays due to toxic environmental exposure. Large industrial centers, intense mining and agricultural activities,
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Chronic aluminum fluoride administration. I. Behavioral observations
This study examined the behavioral effects of chronic ingestion of various monofluoroaluminum complexes (AlF3) in drinking water. Forty young adult male Long-Evans rats were divided into four groups of 10 rats each. The groups received different concentrations of AlF3 in the drinking water from three sample solutions having a total
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Fluoride Developmental Neurotoxicity- Overview of Evidence and Evaluation of Risk at Exposures Due to Artificial Fluoridation.
The topic of fluoride developmental neurotoxicity has received great attention recently due to the publication of several high-profile studies and because of the questions these raise about the safety of water fluoridation, a long-established public health measure to reduce tooth decay. The recent studies have found associations between fluoride exposures
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[Effects of selenium on the damage of learning-memory ability of mice induced by fluoride].
Sodium fluoride added with or without selenite in deionized water was administered to male mice for 8 weeks. The influences of fluoride on learning-memory behavior were tested on Y-maze, and the ultrastructure of Gray 1 synaptic interface in the CA3 area hippocampus was qualitatively analyzed by electron microscopy and computer
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The effect of fluorine exposure of pregnant rats on the learning and memory capabilities of baby rats
Objective: Explore the effect and possible mechanisms of fluorine exposure of pregnant rats passing through placental barriers on the learning and memory capabilities of baby rats. Method: Open field behavior and a water maze test were used to observe the effects on the spontaneous behavior and learning and memory on baby
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