Abstract
Objective: Explore the effect of different doses of chronic exposure of fluoride on rat learning and memory behavior. Method: Selected 46 Wistar rats, randomly divided them into a control group, low-fluoride group, and high-fluoride group, had them respectively drink tap water (control group), 100 mg/L (low-fluoride group), and 200 mg/L (high-fluoride group) sodium fluoride solutions, then five months later used a Y-maze test to observe the effect of chronic fluorosis on the learning and memory behavior of the rats. Results: Compared to the number of times required for the control group to learn the Y-maze test (58.83 +/- 25.12), there was a significant increase (P<0.05) in the number of times required by the low-fluoride group (73.95 +/- 9.77) and high-fluoride group (77.37 +/- 8.69) to learn it, and although the number of times required to learn it increased with the fluoride exposure dose, it was not statistically significant (P>0.05). Conclusion: The results indicate that chronic fluorosis has a significant effect on rat learning and memory behavior.
(Translated by Alta Language Services in February 2014, courtesy of Fluoride Action Network)
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Research on the neurobehavioural function of workers occupationally exposed to fluoride.
Sixty-five operations workers (all males) in an electrolytic aluminum production facility were divided into two groups. The first group of 37 was employed for more than 5 years, and the second group of 28 for 5 years or less. These men had no history of liver, kidney, or immune-related disease. X-ray tests indicated that they were not suffering
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Fluoride Developmental Neurotoxicity- Overview of Evidence and Evaluation of Risk at Exposures Due to Artificial Fluoridation.
The topic of fluoride developmental neurotoxicity has received great attention recently due to the publication of several high-profile studies and because of the questions these raise about the safety of water fluoridation, a long-established public health measure to reduce tooth decay. The recent studies have found associations between fluoride exposures
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Psychopharmacology of fluoride: a review
Although the blood-brain barrier is relatively impermeable to fluoride, it does not pose an absolute barrier and fluoride has the ability to enter the brain. The literature was examined to assess the quality of the evidence for cerebral impairment occurring due to exposure to fluoride from therapeutic or environmental sources.
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Gut microbiota perturbations and neurodevelopmental impacts in offspring rats concurrently exposure to inorganic arsenic and fluoride.
Many “hot spot” geographic areas across the world with drinking water co-contaminated with inorganic arsenic (iAs) and fluoride (F-), two of the most common natural contaminants in drinking water. Both iAs and F- are known neurotoxins and affect neurodevelopment of children. However, very few studies have investigated the neurodevelopmental effects
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Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: an ecological association
Background: Epidemiological and animal-based studies have suggested that prenatal and postnatal fluoride exposure has adverse effects on neurodevelopment. The aim of this study was to examine the relationship between exposure to fluoridated water and Attention-Deficit Hyperactivity Disorder (ADHD) prevalence among children and adolescents in the United States. Methods: Data on ADHD
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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