Abstract

Objective To study the effects of fluoride exposure on performance in water labyrinth and monoamine neurotransmitters of rats.

Methods Forty SD rats were divided randomly into 4 groups:control group,high-fluoride exposed group,medium-fluoride exposed group and low fluoride exposed group.These 4 groups of rats were exposed to different concentrations (0,5,10,20 mg/kg) of sodium fluoride (NaF) for 90 consecutive days,and their behaviors that they learned to perform a water labyrinth task and monoamine neurotransmitters(DA and 5-HT) levels were tested.

Results There were no significant difference in swimming duration among 0,5 and 10 mg/kg groups,while rats in 20 mg/kg group had notable more swimming time(P0.05),and DA level significantly decreased compared with the control group(P0.05),no significantly difference in 5-HT level were found among all groups.

Conclusion The results demonstrate that fluoride exposure may develop an adverse effect on the learning capacity of rats,this may be caused by monoamine neurotransmitters levels alteration.

• Related Studies :

  • Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice.

    SUMMARY: Learning-memory behavior was tested in mice on a Y-maze after they drank water containing different concentrations of sodium fluoride. Impairment of the structure of the Gray I synaptic interface in the CA3 area of the hippocampus was analyzed quantitatively by electron microscopy and a computer imaging processor. The main

  • Gestational exposure to fluoride impairs cognition in C57 BL/6 J male offspring mice via the p-Creb1-BDNF-TrkB signaling pathway.

    Highlights Pregnant mice were exposed to environmentally relevant doses of sodium fluoride from GD1 to GD20. Exposure to sodium fluoride resulted in structural and functional impairments in male offspring mouse hippocampus. The activation of P-Creb1 signaling pathway played a role in sodium fluoride-induced cognitive impairment. We provided new insight

  • DRAFT NTP Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects

    This DRAFT Monograph is distributed solely for the purpose of pre-dissemination peer review and does not represent and should not be construed to represent any NTP determination or policy. Background: Previous reviews of epidemiological studies, including a 2006 evaluation by the National Research Council (NRC), found support for an association between

  • Cognitive Decline of Rats with Chronic Fluorosis Is Associated with Alterations in Hippocampal Calpain Signaling.

    The study was designed to evaluate an influence of excessive fluoride (F-) intake on cognitive capacities of adult rats and on proteins of memory-related calpain signaling in hippocampus. Control animals were given water with natural F- content of 0.4 ppm; rats from other groups consumed the same water supplemented with 5,

  • Sirt3-mediated mitochondrial dysfunction is involved in fluoride-induced cognitive deficits.

    Highlights Fluoride induces cognitive deficits in mice. Fluoride exposure results in neural/synaptic injury in the hippocampus of mice. Mitochondrial dysfunction contributes to neural/synaptic alternations. Inhibition of Sirt3 is involved in the fluoride-evoked mitochondrial abnormalities. Abstract Excessive fluoride is capable of inducing cognitive deficits, but the mechanisms remain elusive. This study aimed

• Related FAN Content :

  • Fluoride's Effect on Fetal Brain

    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching

  • Fluoride & IQ: 76 Studies

    • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.