Abstract
Objective To study the effects of fluoride exposure on performance in water labyrinth and monoamine neurotransmitters of rats.
Methods Forty SD rats were divided randomly into 4 groups:control group,high-fluoride exposed group,medium-fluoride exposed group and low fluoride exposed group.These 4 groups of rats were exposed to different concentrations (0,5,10,20 mg/kg) of sodium fluoride (NaF) for 90 consecutive days,and their behaviors that they learned to perform a water labyrinth task and monoamine neurotransmitters(DA and 5-HT) levels were tested.
Results There were no significant difference in swimming duration among 0,5 and 10 mg/kg groups,while rats in 20 mg/kg group had notable more swimming time(P0.05),and DA level significantly decreased compared with the control group(P0.05),no significantly difference in 5-HT level were found among all groups.
Conclusion The results demonstrate that fluoride exposure may develop an adverse effect on the learning capacity of rats,this may be caused by monoamine neurotransmitters levels alteration.
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Attenuating effect of Vitamin E on the deficit of learning and memory of rats with chronic fluorosis: the mechanism may involve muscarinic acetylcholine receptors.
The protective role of vitamin E (Vit E) against neurotoxicity induced by fluorosis was investigated by using Sprague-Dawley (SD) rats fed with 50 ppm fluoride in drinking water for 10 months. Spatial learning and memory of rats were measured by the Morris water maze test; the expressions of M1 and
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Alterations of nAChRs and ERK1/2 in the brains of rats with chronic fluorosis and their connections with the decreased capacity of learning and memory.
In order to reveal the mechanism of the decreased ability of learning and memory induced by chronic fluorosis, nicotinic acetylcholine receptors (nAChRs) and the pathway of extracellular signal regulated protein kinase (ERK1/2) were investigated by using the rats fed with different concentrations of sodium fluoride for 6 months. Spatial learning
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Decreased learning ability and low hippocampus glutamate in offspring rats exposed to fluoride and lead.
Fluoride (F) and lead (Pb) are two common environmental pollutants which are linked to the lowered intelligence, especially for children. Glutamate, a major excitatory neurotransmitter in the central nervous system, plays an important role in the process of learning and memory. However, the impact of F and Pb alone or
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Evaluation of Metformin and Dehydrozingerone against fluorosis induced neurodevelopmental toxicity in preclinical models.
Background: Inorganic fluoride is widely used in dental practices to treat problems like dental caries and also to prevent bone related issues. It has been reported that exposure to excess amounts of fluoride either through drinking water or other sources impairs vital functions of the body and can
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[Effects of high fluoride and low Iodine on learning-memory and TchE of brain in offspring rats].
Objective To study the effect of high level fluoride and low level iodine on learning-memory in offspring rats and possible mechanism. Methods Thirty-two Wistar rats were randomly divided into four groups each of eight (female:male=(3:1).) The rats were treated with high fluoride (100 and 150 mg NaF/L), low iodine (0.0855 mg/kg),
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