Abstract

Objective To study the effects of fluoride exposure on performance in water labyrinth and monoamine neurotransmitters of rats.

Methods Forty SD rats were divided randomly into 4 groups:control group,high-fluoride exposed group,medium-fluoride exposed group and low fluoride exposed group.These 4 groups of rats were exposed to different concentrations (0,5,10,20 mg/kg) of sodium fluoride (NaF) for 90 consecutive days,and their behaviors that they learned to perform a water labyrinth task and monoamine neurotransmitters(DA and 5-HT) levels were tested.

Results There were no significant difference in swimming duration among 0,5 and 10 mg/kg groups,while rats in 20 mg/kg group had notable more swimming time(P0.05),and DA level significantly decreased compared with the control group(P0.05),no significantly difference in 5-HT level were found among all groups.

Conclusion The results demonstrate that fluoride exposure may develop an adverse effect on the learning capacity of rats,this may be caused by monoamine neurotransmitters levels alteration.

• Related Studies :

  • Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the a7 nicotinic receptor and oxidative stress.

    Daily exposure to fluoride (F) depends mainly on the intake of this element with drinking water. When administered during gestation and lactation, F has been associated with cognitive deficits in the offspring. However, the mechanisms underlying the neurotoxicity of F remain obscure. In the current study, we investigated the effects

  • Neonatal sevoflurane anesthesia induces long-term memory impairment and decreases hippocampal PSD-95 expression without neuronal loss.

    AIM: Volatile anesthetics are widely used in the clinic, and sevoflurane is the most prevalent volatile anesthetic in pediatric anesthesia. Recent findings question the potential risks of volatile anesthetics on brain development. Evidence suggests that sevoflurane may cause neuronal deficiency. This study investigates the long-term effect of sevoflurane in the

  • Changes in learning and memory ability and brain cholinesterase activity in the rats with coal burning fluorosis.

    Objective: To observe the influence of coal burning fluorosis on learning and memory ability in rats and reveal its possible mechanisms. Methods: Healthy 48 SD rats were divided into control, low-fluoride and high-fluoride group. All rats in fluoride exposed groups were fed with the eom polluted by drying processes with

  • Learning and memory obstacles and changes in brain tissue growth inhibitors from brick tea fluoride and aluminum poisoning of rats

    Objective: Explore the active mechanisms of growth inhibitors (somatostatin, SS) participating in learning and memory obstacles from brick tea fluoride and aluminum poisoning of rats. Method: Based on the tea-drinking habits of herders, a rat chronic brick tea fluoride and aluminum poisoning animal model was established, and randomly divided into

  • Neurobehavioral toxicity produced by sodium fluoride in drinking water of laboratory rats

    The effect of exposure to different concentrations of sodium fluoride (Na-F) for different durations on learning and memory tasks in rats (non-associative and associative learning) was assessed in our study. Three groups of fifteen pregnant Wistar female rats each, were administered Na-F in drinking water at one of three concentrations;

• Related FAN Content :

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.

  • Fluoride & IQ: 69 Studies

    As of June 2021, a total of 77 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 69 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.

  • Fluoride's Effect on Fetal Brain

    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching