Abstract

[Objective] To investigate the effect of iodine and selenium on learning memory behavior impairment induced by fluorosis and blood biochemical criterion change of rats. To study the antagonism of iodine and selenium on fluorosis. [Methods] After the rats with fluorosis drinking water with different concentrations of iodine ( I) and selenium ( Se) for a long time, their learning memory abilities were measured by way of Y- maze, and the blood biochemical criterions were determined at the same time. [Results] The learning memory abilities of rats in high F group, high I/high F group, and low I/high F group were significantly lower than control group, while the learning memory abilities of rats given proper concentration I and Se increased significantly. The blood biochemical criterions of high F group, high I/high F group, and low I/high F group presented marked differences from that of groups given proper concentration I and Se. [Conclusion] Proper concentration I and Se have obvious antagonism against rat fluorosis. The antagonism may be related with the changes of blood biochemical criterion.

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