Abstract
Bone specimens from 42 patients with end-stage renal disease and from 9 patients without renal or bone disease have been analyzed for the content of fluoride, calcium, and phosphorus. Thirty-one patients were treated with chronic hemodialysis for periods ranging up to 56 months by employing dialysate made up with tap water containing 1 ppm fluoride. Fluoride content of cortical hard bone was increased in the great majority of patients with kidney disease. There was no significant difference in bone fluoride content between the patients who were dialyzed and those who were not. However, the content of calcium and phosphorus was lower in the patients treated by hemodialysis. There was no correlation between duration of uremia or number of dialyses and bone fluoride content. In 4 patients, 3 with kidney disease and 1 without, soft bone and soft tissue had much higher fluoride content than cortical bone.
-
-
High fluoride concentrations in the serum and bone of patients with chronic renal failure
The aim was to study the effect of ingested fluoride in patients with chronic renal failure (CRF). Serum fluoride concentrations were measured in 104 subjects, who formed three groups: nondialyzed CRF, dialyzed CRF, and a control group. The iliac bone fluoride was measured in 20 subjects. Serum, urine and water
-
Association between fluoride, magnesium, aluminum and bone quality in renal osteodystrophy
INTRODUCTION: Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. A number of studies have linked
-
Fluoride and strontium accumulation in bone does not correlate with osteoid tissue in dialysis patients
BACKGROUND: Osteomalacia is now a rare disease in dialysis patients in developed countries since the withdrawal of aluminium overload. The involvement of fluoride and strontium in the pathogenesis of the disease has been suggested. The aim of this study was to investigate a possible association between osteomalacia in dialysis patients
-
Effects of fluoride on bone metabolism in patients with hemodialysis
The maior pathway of fluoride elimination from the human body is the kidney. The discharge of fluoride into urine depends on the clearance of the kidney. Fluoride in serum of hemodialysis patients is higher than that of healthy subjects. Fluoride is not reduced sufficiently with hemodialysis. Those patients are in
-
Osteomalacia is associated with high bone fluoride content in dialysis patients
Osteomalacia is now rarely observed in hemodialyzed patients since the prevention of aluminum intoxication and vitamin D deficiency. However, this disorder is still present and may be responsible for bone fractures. Fluoride overload is responsible for mineralization defects. We therefore prospectively measured the bone fluoride content in all dialysis osteomalacic
Related Studies :
-
-
-
Fluoride & Osteomalacia
One of fluoride's most well-defined effects on bone tissue is it's ability to increase the osteoid content of bone. Osteoid is unmineralized bone tissue. When bones have too much of it, they become soft and prone to fracture -- a condition known as osteomalacia. As shown below, fluoride has repeatedly been
-
Annapolis: Water Fluoridation Linked to Death of Dialysis Patient
EVENING CAPITAL (Annapolis, Maryland) November 29, 1979 Fluoride Linked to Death by Mary Ann Kryzankowicz Staff Writer Fluoride poisoning has been definitely linked to the death of a 65-year-old kidney dialysis patient who became ill during a blood cleaning process Nov 11. State Medical Examiner Dr. (illegible) Guard has ruled that Lawrence Blake, 65, of Arundel
-
Unheeded Warnings: Government Health Authorities Ignore Fluoride Risk for Kidney Patients
Despite the well known fact that individuals with kidney disease are at much higher risk of fluoride toxicity than the general population, there has yet to be any attempt in the United States, or any other country that practices mass-scale water fluoridation to determine the prevalence of fluoride-related effects (e.g.,
-
Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
-
Mayo Clinic: Fluoridation & Bone Disease in Renal Patients
The available evidence suggests that some patients wtih long-term renal failure are being affected by drinking water with as little as 2 ppm fluoride. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers and if fluoride is indeed the cause. It would seem prudent, therefore, to monitor the fluoride intake of patients with renal failure living in high fluoride areas.
Related FAN Content :
-