Abstract
With growing experience of the long-term treatment of patients with end stage renal disease by hemodialysis, the safety of fluoridated water supply for dialysate and the effect on the bone metabolism has been discussed.
In this study, concentrations of fluoride (F), calcium (Ga). aluminum (AI) and biochemical indices of bone metabolism, such as bone gla protein (BGP), parathyroid hormone (PTH), alkaline phosphatase (ALP) in serum, and the bone mineral density of both radius (radial-BD) and lumbar spine (spinal-BD) were analyzed in 95 patients (45 males and 50 females) with hemodialysis to clarify the combined effects of F concentration and treatment of hemodialysis on the bone metabolism in those patients.
Serum F, BOP, and PTH in the patients with hemodialysis were significantly higher than those in healthy subjects. Although radial-BD decreased with duration of hemodialysis in both male and female patients, spinal-BD did not parallel to the changes in radial·BD. In the correlation matrices of the observation items in the patients. the pairs of items having a good correlation coefficient were F and BGP, F and spinal-BD, BGP and PTH in male subjects. and F and ALP, BGP and PTH in female patients.
From these results. it was suggested that absorbed F strongly affected the metabolism of bone, especially cancellous bone in the patients with long-term hemodialysis.
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Hemodialyzability of ionizable fluoride in hemodialysis session
The fluoride ion content in serum and in dialysate medium was determined by means of a fluoride ion-selective electrode in 29 patients undergoing hemodialysis treatment. Abnormally high serum fluoride of 65.9 +/- 28.3 microg l(-1) at the beginning and 46.5 +/- 26.7 microg l(-1) at the completion of the hemodialysis
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Serum and urine fluoride concentration: relationships to age, sex and renal function in a non-fluoridated population
Serum and urine fluoride levels were determined in 250 healthy subjects (15-90 years, 122 men and 128 women) residing in Catalonia, Spain, and in 150 patients (20-81 years, 84 men and 66 women) with chronic renal failure undergoing regular dialysis treatment, living in the same geographical area, to determine normal
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High fluoride concentrations in the serum and bone of patients with chronic renal failure
The aim was to study the effect of ingested fluoride in patients with chronic renal failure (CRF). Serum fluoride concentrations were measured in 104 subjects, who formed three groups: nondialyzed CRF, dialyzed CRF, and a control group. The iliac bone fluoride was measured in 20 subjects. Serum, urine and water
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Serum fluoride concentrations in renal insufficiency
In an area with non-fluoridated water (F content, 0.061 ppm), serum fluoride concentrations as measured with an ion specific electrode were as follows: controls (N = 13), 0.0127 ppm + 0.0057 (mean + SD); renal insufficiency (N = 10), 0.0452 ppm + 0.0151; chronic hemodialysis (N = 11), 0.0424 +
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Human urinary fluoride excretion as influenced by renal functional impairment
The effects of renal function on human renal fluoride (F-) excretion and serum F- concentrations were studied in subjects with normal renal function, in patients with variable degrees of renal insufficiency and in patients undergoing regular hemodialysis treatment. The mechanisms of human renal F- excretion include glomerular filtration and tubular
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