Excerpt:

The concept that osteomalacia becomes progressively worse on chronic dialysis was reinforced by the findings in the repeat bone biopsies in that 6 of the 8 patients showed a significant increase in their osteoid index. . . . Thus, the progression of osteomalacia appears to be the main reason for the increasing incidence of bone pain and pseudofractures which we and others have observed in patients on chronic dialysis for periods longer than 6 months. Jowsey, et al, has reported similar findings. When the patients reported by Kim, et al. are classified in the same manner as ours were, a similar higher incidence of osteomalacia and absence of severe osteitis fibrosa was observed in patients on chronic dialysis for more than 6 months… The reason(s) for the progression of osteomalacia, which we observed in our chronic dialysis patients, remain(s) unclear. Factors which could result in impaired mineralization which must be considered include fluoride, hypermagnesemia, and phosphate depletion.

Print PDF

• Related Studies :

  • Association between fluoride, magnesium, aluminum and bone quality in renal osteodystrophy

    INTRODUCTION: Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. A number of studies have linked

  • Comparison of renal osteodystrophy in patients dialyzed with deionized and non-deionized water

    Discussion There are 2 major types of osteodystrophy which occur in various combinations in dialysis patients. The first and most commonly predominant is secondary hyperparathyroidism. This appears to be preventable, or at least controllable, with a bath calcium concentration above 6 mg%. The second type is osteomalacia. In certain centers it

  • Osteomalacia is associated with high bone fluoride content in dialysis patients

    Osteomalacia is now rarely observed in hemodialyzed patients since the prevention of aluminum intoxication and vitamin D deficiency. However, this disorder is still present and may be responsible for bone fractures. Fluoride overload is responsible for mineralization defects. We therefore prospectively measured the bone fluoride content in all dialysis osteomalacic

  • Bone disease in hemodialysis patients with particular reference to the effect of fluoride

    Forty-one patients on our chronic hemodialysis program were assessed for the degree of progression of bone disease over an average period of 46 months. Seven patients were using a fluoridated dialysate. Four of these seven patients developed a marked increase in osteoid as judged by bone biopsy, while in the

  • Fluoridation and bone disease in renal patients

    About the Authors: William J Johnson, director of the Mayo Artificial Kidney Center and professor of medicine with the Division of Nephrology at the Mayo Clinic, has been involved in the study of calcium and phosphorus metabolism and renal osteodystrophy, potassium metabolism, and uremic neuropathy. He is past chairman of the Minnesota

• Related FAN Content :

  • Fluoridation, Dialysis & Osteomalacia

    In the 1960s and 1970s, doctors discovered that patients receiving kidney dialysis were accumulating very high levels of fluoride in their bones and blood, and that this exposure was associated with severe forms of osteomalacia, a bone-softening disease that leads to weak bones and often excruciating bone pain. Based on

  • Fluoride & Osteomalacia

    One of fluoride's most well-defined effects on bone tissue is it's ability to increase the osteoid content of bone. Osteoid is unmineralized bone tissue. When bones have too much of it, they become soft and prone to fracture -- a condition known as osteomalacia. As shown below, fluoride has repeatedly been

  • Similarities between Skeletal Fluorosis and Renal Osteodystrophy

    It is quite possible, and indeed likely, that some kidney patients diagnosed with renal osteodystrophy are either suffering from skeletal fluorosis or their condition is being complicated/exacerbated by fluoride exposure.

  • Fluoride & Osteoarthritis

    While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.

  • Unheeded Warnings: Government Health Authorities Ignore Fluoride Risk for Kidney Patients

    Despite the well known fact that individuals with kidney disease are at much higher risk of fluoride toxicity than the general population, there has yet to be any attempt in the United States, or any other country that practices mass-scale water fluoridation to determine the prevalence of fluoride-related effects (e.g.,