Abstract
The cardiotoxic effect of various dosage of sodium fluoride was investigated. Three-week-old male Wistar rats were fed on normal fodder and distilled water containing different dosages (0, 25, 50, 100 and 150 mg/litre) of sodium fluoride for 6 months to establish an animal model of chronic fluorosis. Electrocardiogram (ECG) was taken after the experiment for 6 months to observe the effects of fluoride. The morphological changes were observed under transmission electron and light microscopes. There was a shortness of Q-T interval in rats with fluorosis. The morphological changes observed in myocardial tissue under the light microscope were indistinct transverse striation and myolysis or myocardial fibre coagulation. The mitochondria were swollen under transmission electron microscope in rats with fluorosis. It is concluded that fluorosis can cause myocardial cell damage and changes in myocardial structure and ECG in rats.
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Changes of the heart muscle due to chronic fluorosis. Part 2: Experimental studies on the effects of sodium fluoride upon the heart muscle of rabbits
In the electrocardiogram of rabbits given sodium fluoride orally, a pattern of myocardial damage was observed, namely depressed ST, inverted T, prolonged QT interval, multifocal ventricular premature contraction, bundle branch block, and pulmonary P. Histologically, regressive degeneration, cellular infiltration, hyperemia, hemorrhages and thickening of vessel wall were noted in the
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Electrocardiogram analysis of patients with skeletal fluorosis
To investigate the degree of myocardial damage resulting from endemic fluorosis, electrocardiograms of 136 skeletal fluorosis patients from an endemic fluorosis area were compared with electrocardiograms of a control group of 40 normal patients from a non-endemic fluorosis area. The results show that fluoride in drinking water consumed over time
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Effects of chronic fluorosis on electrocardiogram in dogs
The aim of this study was to determine the effects of chronic fluorosis on the electrocardiogram (ECG) in dogs. A total of sixteen mixed breed dogs (8 fluorotic and 8 healthy), 2 to 3 years old and weighing 18–30 kg, were used in this study. The eight dogs with chronic
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Analyses of ECGs in 271 cases with dental fluorosis
Our team performed investigations in Yuqing Village and Guanfang Village (1) which were seriously affected by endemic fluorosis, from September to October 1985; those two villages are only 1,500 meters distant from Mangbu District of Zhenxiong County, and the life and production conditions in these two villages are similar to
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Effects of fluorosis on QT dispersion, heart rate variability and echocardiographic parameters in children - Original Investigation
OBJECTIVE: Chronic fluoride poisoning is called fluorosis. The aim of the study was to investigate effects of fluorosis on cardiovascular system in children by measuring QT dispersion (QTd), corrected QT dispersion (QTcd), heart rate variability (HRV) and echocardiography findings. METHODS: Thirty-five children with dental fluorosis and 26 children as control group
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Fluoride & Arteriosclerosis
Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the
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Fluoride & Arterial Calcification
The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis
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Fluoride & Myocardial Damage
Structural damage to the heart resulting from fluoride toxicity has been observed in numerous human and animal studies. The general features of this damage include cloudy swelling, vacuolization or vacuolar degeneration, hemorrhages, interstitial edema, fibrous necrosis, dissolution of nuclei, and thickening of the vessel walls in the heart muscle (Basha
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Fluoride, Blood Pressure and Hypertension
Individuals with blood pressure readings that exceed 140/90 are considered hypertensive. Hypertension can increase the risk of stroke, heart attack, heart failure, aortic aneurysms, and peripheral arterial disease. An association between increased fluoride in ground water and increased prevalence of hypertension has been observed, especially among adult males (Amini et
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Fluoride & Electrocardiogram Abnormalities
An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems
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