Abstract

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  • Prenatal and postnatal ingestion of fluorides: fourteen years of investigation -- final report*.

    SUMMARY Data is presented showing that fluoride ingested by gravid women enters the maternal circulation, is stored in the placenta and passes through the placental barrier to enter the foetal blood supply. Evidence is presented that the fluoride in the foetal blood supply affects the developing teeth to make them more resistant

  • Enhancement of inflammation by fluorides

    Application of ammonium fluoride under an occlusive patch to the abdomen of a rabbit converts a simple scratch into a double row of sterile pustules. Sodium fluoride produces a similar response, but ammonium chloride does not produce pustules. . . . It appears that tissue damage and the presence of fluorides

  • NaF skin reaction to topical fluoride: metabolic and histological changes

    Topical and systemic administration or contact with fluorides has produced various forms of cutaneous reactivity. These studies, conducted with 150-400 g. Sprague-Dawley rats, investigated the effect of topical application of NaF to a shaved, epidemal abraded region (5 em.) of dorsal skin. After 24 hrs. NaF (1%) produced inflammation of

  • Perioral dermatitis

    Since its description in 1957 by Frumess and Lewis (1) as a "light-sensitive seborrheid," perioral dermatitis (PD) has been a perplexing entity. It characteristically presents as a chronic eruption consisting of papules and pustules that develop on irregular areas of erythema and edema. the eruption is most prominent in the

  • The effect of stannous fluoride and stannous chloride on inflammation

    Scratches were made to the depth of the upper dermis on the abdomen of rabbits. The scratches were covered by patch tests for 18 hours with solutions of stannous fluoride or stannous chloride. Both these substances produced a destructive reaction with intraepidermal polymorphonuclear leukocyte pustules occurring on each side of

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  • Is the Ingestion of Fluoride an Immunosuppressive Practice?

    This paper records several observations which suggest that habitual ingestion of small doses of fluoride, even as small as the 1 mg/L contained in fluoridated water, may decrease the function of the immune system.

  • Case Reports of Hypersensitivity to Ingested Fluorides

    In the 1950s, the renowned allergist George Waldbott discovered that some individuals are hypersensitive to ingested fluoride. In a series of case reports and double-blind studies, Waldbott and other doctors found relatively small doses of ingested fluoride, including the consumption of fluoridated water, could induce side effects that would quickly

  • Does Fluoride Ingestion Affect Developing Immune System Cells?

    Considerations, supported by some published experimental evidence, suggest that fluoride released during the resorption of high-fluoride bone may produce detrimental effects not only on bone cells but on developing cells of the immune system.

  • Allergic Reactions from Fluorides

    Six cases are described with allergic manifestations from fluorides. The symptoms were reproduced by administering an aqueous fluoride solution either by ingestion, injection or local application. Control tests had no such effect. The patients had no way of knowing which solution contained fluoride.

  • Hypersensitive Reactions to Topical Fluorides

    Ever since fluoride toothpastes were introduced in the mid 1950s, studies in the scientific literature have documented adverse skin reactions from the use of topical fluoride products such as toothpaste. These skin reactions include: perioral dermatitis, stomatitis, and urticaria. Although many dermatologists now consider fluoride toothpaste to be a common cause of perioral dermatitis, the dental community