Abstract
The topical application of sodium fluoride to abraded rat skin produced several morphological and biochemical effects. Related to the degranulation of dermal mast cells, skin histamine concentration was increased, fluorides were absorbed into the skin, and deposited mainly kin mitochondria. Dermal histamine binding was decreased for both H1 and H2 receptors with reduced binding sites, but epidermal adenyl cyclase was activated by fluorides. The response of the rat skin to fluorides involves a sequence of changes by which the potentiation of an inflammatory response also involves alterations in specific histamine receptors and a histamine-specific adenyl cyclase system.
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Allergy to fluoride
Six children and one adult exhibited various allergic reactions after the use of toothpaste and vitamin preparations containing fluoride. The following conditions were encountered: Urticaria, exfoliative dermatitis, atopic dermatitis, stomatitis, gastro-intestinal and respiratory allergy.
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NaF skin reaction to topical fluoride: metabolic and histological changes
Topical and systemic administration or contact with fluorides has produced various forms of cutaneous reactivity. These studies, conducted with 150-400 g. Sprague-Dawley rats, investigated the effect of topical application of NaF to a shaved, epidemal abraded region (5 em.) of dorsal skin. After 24 hrs. NaF (1%) produced inflammation of
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The effect of stannous fluoride and stannous chloride on inflammation
Scratches were made to the depth of the upper dermis on the abdomen of rabbits. The scratches were covered by patch tests for 18 hours with solutions of stannous fluoride or stannous chloride. Both these substances produced a destructive reaction with intraepidermal polymorphonuclear leukocyte pustules occurring on each side of
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Fluoroderma
Papulonodular eruptions from certain bromide and iodide preparations are widely recognized entities, but skin lesions following fluoride ingestion are rare. Modern prophylaxis for postirradiation dental caries includes the use of fluoride gel preparations applied to the teeth. In two patients receiving such therapy a papulonodular eruption developed, similar to the
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Enhancement of inflammation by fluorides
Application of ammonium fluoride under an occlusive patch to the abdomen of a rabbit converts a simple scratch into a double row of sterile pustules. Sodium fluoride produces a similar response, but ammonium chloride does not produce pustules. . . . It appears that tissue damage and the presence of fluorides
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Fluoride Toothpaste: A Cause of Acne-like Eruptions
I feel that I should share with my colleagues in dermatology an observation relative to the treatment of problem acne.
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Fluoride Dentrifice and Stomatitis
Statistical data of 133 patients who have been using fluoride dental cream or powder have been presented. Each has developed intraoral ulcerative lesions. Many have been treated for other complaints without clearance of the lesions. Age is not significant. Repeated insults with the fluoride dentrifices produced increasingly severe excoriations. There seems to be nothing specific about the lesions to differentiate them from other diseases of an oral nature.
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Hypersensitive Reactions to Topical Fluorides
Ever since fluoride toothpastes were introduced in the mid 1950s, studies in the scientific literature have documented adverse skin reactions from the use of topical fluoride products such as toothpaste. These skin reactions include: perioral dermatitis, stomatitis, and urticaria. Although many dermatologists now consider fluoride toothpaste to be a common cause of perioral dermatitis, the dental community
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Is the Ingestion of Fluoride an Immunosuppressive Practice?
This paper records several observations which suggest that habitual ingestion of small doses of fluoride, even as small as the 1 mg/L contained in fluoridated water, may decrease the function of the immune system.
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Allergy to Fluoride
Six children and one adult exhibited various allergic reactions after the use of toothpaste and vitaimin preparations containing fluoride. The following conditions were encountered: Urticaria, exfoliative dermatitis, atopic dermatitis, stomatitis, gastro-intestinal and respiratory allergy.
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