Abstract
The topical application of sodium fluoride to abraded rat skin produced several morphological and biochemical effects. Related to the degranulation of dermal mast cells, skin histamine concentration was increased, fluorides were absorbed into the skin, and deposited mainly kin mitochondria. Dermal histamine binding was decreased for both H1 and H2 receptors with reduced binding sites, but epidermal adenyl cyclase was activated by fluorides. The response of the rat skin to fluorides involves a sequence of changes by which the potentiation of an inflammatory response also involves alterations in specific histamine receptors and a histamine-specific adenyl cyclase system.
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Perioral dermatitis from high fluoride dentifrice: a case report and review of literature
Perioral dermatitis is a papulopustular eruption, commonly related to the inappropriate application of topical corticosteroids with occasional reports of inhaled corticosteroids and decreased personal hygiene. We present a case of a 45-year-old female with a one-year history of perioral dermatitis related to the use of highly fluoridated toothpaste commenced to
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The effect of stannous fluoride and stannous chloride on inflammation
Scratches were made to the depth of the upper dermis on the abdomen of rabbits. The scratches were covered by patch tests for 18 hours with solutions of stannous fluoride or stannous chloride. Both these substances produced a destructive reaction with intraepidermal polymorphonuclear leukocyte pustules occurring on each side of
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Contact dermatitis and stomatitis due to amine fluoride
Case Report For prevention of dental caries, a 17-year-old boy had intermittently used a gel containing different fluoride compounds over a period of 2 years. In the last 2 months, 1 to 2 days after application, he had developed itchy perioral erythematous papules and plaques, with vesicles of the oral mucosa.
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Contact urticaria from sodium fluoride
Sodium fluoride (NaF) is. used for the treatment and prevention of dental caries. Its application to the teeth makes the dental enamel more resistant to acid. In some communities, it is added to the water if the geographical area lacks sufficient fluoride. Another method of preventing dental caries is the
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Fluoride tooth paste: a cause of perioral dermatitis
Since its description in 1957 by Frumess and Lewis as a “light-sensitive seborrheid,” perioral dermatitis (PD) has continued to be a perplexing entity. (1) Many causes have been postulated, including sunlight sensitivity, birth control pills, emotional stress, fluorinated steroid creams, Candida albicans, and rosacea. We have gathered clinical and historical data implicating
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Is the Ingestion of Fluoride an Immunosuppressive Practice?
This paper records several observations which suggest that habitual ingestion of small doses of fluoride, even as small as the 1 mg/L contained in fluoridated water, may decrease the function of the immune system.
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Fluoride & Perioral Dermatitis
Perioral dermatitis (PD) is a common rosacea-like dermatitis that was never reported prior to the mid-fifties. Although it can affect both sexes and all ages, most patients are women ages 20-50 years. Patients with PD frequently report a pre-existing tendency to blush. This disease is most likely multifactorial in origin, and fluoride preparations in dentrifices probably have played a role as precipitator.
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Allergic Reactions from Fluorides
Six cases are described with allergic manifestations from fluorides. The symptoms were reproduced by administering an aqueous fluoride solution either by ingestion, injection or local application. Control tests had no such effect. The patients had no way of knowing which solution contained fluoride.
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Hypersensitive Reactions to Topical Fluorides
Ever since fluoride toothpastes were introduced in the mid 1950s, studies in the scientific literature have documented adverse skin reactions from the use of topical fluoride products such as toothpaste. These skin reactions include: perioral dermatitis, stomatitis, and urticaria. Although many dermatologists now consider fluoride toothpaste to be a common cause of perioral dermatitis, the dental community
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Physician's Desk Reference: Fluoride Hypersensitivity
The following are excerpts from various editions of the Physicians' Desk Reference (PDR). "In hypersensitive individuals, fluorides occasionally cause skin eruptions such as atopic dermatitis, eczema or urticaria. Gastric distress, headache and weakness have also been reported. These hypersensitivity reactions usually disappear promptly after discontinuation of the fluoride. In rare cases,
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