Abstract
Objective To study the serotonin neuron in rat with chronic fluorosis.
Methods Animal model of chronic fluorosis in male rats was established with administration of large doses fluoride in drinking water. The qualitative and quantitative analysis of serotonin (5-HT) neurons in nucleus raphe magnus with immunocytochemical technique was done.
Results The results showed that the number of 5-HT positive neurons in nucleus raphe magnus decreased in fluorosis group with the declared 5-HT positive particles in cytoplasm. With cell image analysis, the 5-HT contents in the 5-HT neurons decreased significantly in fluorosis group.
Conclusion These results suggest that the administration of larger doses of fluoride will directly damage the central nervous system.
-
-
Effect of fluorosis on mice learning and memory behaviors and brain SOD activity and MDA content
Objective: Explore the brain mechanism of the effect of fluorosis on learning and memory behavior. Method: A method combining behavioral observation and biochemical testing was used to study the effects of long-term drinking different concentrations of sodium fluoride on mouse learning and memory behavior and changes in content of brain
-
The antioxidant system enzymes’ activity in rats’ brain, intoxicated with sodium fluoride in subtoxic doses.
The aim of the study was to assess the activity of enzymes in the antioxidant system in the brain of rats subjected to intoxication with sodium fluoride in subtoxic doses. Methods. The studies were conducted on sexually mature Wistar rats weighing 180-220 g, subjected to oral exposure by means of a
-
Fluoride Induces Neuroinflammation and Alters Wnt Signaling Pathway in BV2 Microglial Cells.
Fluoride is a common element in nature and our daily life, and excessive intake of this element can cause fluorosis and irreversible brain damage. The toxic effects of fluoride on the central nervous system may be attributed to the release of inflammatory cytokines and ROS. GSK3B is a key protein
-
Detrimental Effects of Sodium Fluoride on the Expression of Insulin Receptor in the Olfactory Bulb and Hippocampus of Male Mice.
Fluoride exposure is associated with lowered cognitive function ability, intelligence quotient, and mental decline, especially in children. The brain insulin receptor (IR) signaling system is related to neuronal plasticity and consequent cognitive ability. In our previous study, NaF exposure decreased IR expressions in olfactory bulb (OB) and hippocampus after Y-maze
-
Molecular mechanism of brain impairment caused by drinking-acquired fluorosis and selenium intervention
This study investigated the molecular mechanism of brain impairment induced by drinking fluoridated water and selenium intervention. Results showed that the learning and memory of rats in NaF group significantly decreased. Moreover, the number of apoptotic cells, the expression levels of Cytc mRNA and protein, and the expression levels of
Related Studies :
-
-
-
Fluoride & IQ: 74 Studies
• As of May 2022, a total of 83 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 74 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure to
-
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
-
Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
-
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
-
Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
Related FAN Content :
-