Abstract
Objective To study the serotonin neuron in rat with chronic fluorosis.
Methods Animal model of chronic fluorosis in male rats was established with administration of large doses fluoride in drinking water. The qualitative and quantitative analysis of serotonin (5-HT) neurons in nucleus raphe magnus with immunocytochemical technique was done.
Results The results showed that the number of 5-HT positive neurons in nucleus raphe magnus decreased in fluorosis group with the declared 5-HT positive particles in cytoplasm. With cell image analysis, the 5-HT contents in the 5-HT neurons decreased significantly in fluorosis group.
Conclusion These results suggest that the administration of larger doses of fluoride will directly damage the central nervous system.
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Co-exposure to arsenic and fluoride on oxidative stress, glutathione linked enzymes, biogenic amines and DNA damage in mouse brain.
We studied the effects of combined exposure to arsenic and fluoride on (i) brain biogenic amines, oxidative stress and its correlation with glutathione and linked enzymes; (ii) alterations in the structural integrity of DNA; and (iii) brain and blood arsenic and fluoride levels. Efficacy of alpha-tocopherol in reducing these changes
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Confirmation of and explanations for elevated blood lead and other disorders in children exposed to water disinfection and fluoridation chemicals
Silicofluorides (SiFs), fluosilicic acid (FSA) and sodium fluosilicate (NaFSA), are used to fluoridate over 90% of US fluoridated municipal water supplies. Living in communities with silicofluoride treated water (SiFW) is associated with two neurotoxic effects: (1) Prevalence of children with elevated blood lead (PbB>10microg/dL) is about double that in non-fluoridated
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[Effects of fluoride on neural cell adhesion molecules mRNA and protein expression levels in primary rat hippocampal neurons].
OBJECTIVE: To investigate the effects of fluoride on the growth and viability, and mRNA and protein expression levels of neural cell adhesion molecules (NCAM) in primary rat hippocampal neurons. METHODS: The growth and development, the rate of cell survivor, and the mRNA and protein expression levels of NCAM were measured by
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Interplay of ROS and behavioral pattern in fluoride exposed Drosophila melanogaster.
Highlights NaF exposure increases mortality and changes male-female ratio in Drosophila. NaF treatment alters the activities endogenous antioxidant enzymes. Chronic sub-lethal NaF exposure causes increased oxidative damage. NaF decreases brain cell viability and increases DNA damage. NaF exposure alters selected behavioral pattern in Drosophila melanogaster. Reactive oxygen species (ROS) is
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Protective role of tert-butylhydroquinone against sodium fluoride-induced oxidative stress and apoptosis in PC12 cells.
The neurotoxicity of fluoride is associated with oxidative stress due to imbalance between production and removal of reactive oxygen species (ROS). In contrast, induction of detoxifying and antioxidant genes through activation of NF-E2-related factor 2 (Nrf2) has been implicated in preventing oxidative stress and apoptosis in neurodegenerative diseases. The present
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Fluoride's Direct Effects on Brain: Animal Studies
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Fluoride Affects Learning & Memory in Animals
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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Fluoride & IQ: 76 Studies
• As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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