Abstract
Animal models with pathological damage caused by chronic fluorosis to a different extent were duplicated in Wistar rats by feeding them with 66.3 mg/L and 221 mg/L fluorine-containing water for three, five and seven months, respectively. Cholesterol, dolichol and coenzyme Q in animal brain tissues were determined by high performance liquid chromatography. Results showed that no significant difference of cholesterol and dolichol contents in brian tissues between rats with fluorosis and normal controls were detected. Coenzyme Q content of brain tissue in rats fed with fluorine-containing water decreased at early stage of fluorosis, but increased significantly at late stage. It is speculated that changes in content of coenzyme Q could correlate with changes in free radical levels induced by fluorine.
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Effects of fluoride accumulation on some enzymes of brain and gastrocnemius muscle of mice
This study reports accumulation of fluoride and altered activities of some enzymes involved in free-radical metabolism and membrane function in whole brain and gastrocnemius muscle of female mice treated with NaF (20mg/kg/body weight) for 14 days. The body weight and somatic index were decreased, whereas fluoride levels were significantly increased
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[Studies on fluoride concentration and cholinesterase activity in rat hippocampus].
OBJECTIVE: To study the accumulation of fluoride in rat hippocampus and its effect on cholinesterase activity. METHODS: Rats were subchronically exposed to NaF, and fluoride concentration and cholinesterase activity in rat hippocampus were determined. RESULTS: Fluoride concentration in rat hippocampus was significantly correlated with the dosage of fluoride, and there
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Role of triphala on fluoride neuorotoxicity in the rat
To investigate effects of sodium fluoride (NaF) on the cerebellum cerebral hemisphere brain of rats and its possible amelioration by the popular Ayurvedic herbal health product triphala, adult female Wistar rats (Rattus novergicus) were administered 10 mg NaF/kg bw/day and 30 mg triphala/kg bw/day for 30 days. A significant decline in body and brain
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Alterations in plasma and tissue acetylcholinesterase activity following repeated oral exposure of chlorpyrifos alone and in conjunction with fluoride in Wistar Rats
Concurrent exposures of more than one environmental contaminants are commonly encountered by human beings and animals. This study investigated the effect of chlorpyrifos alone and in conjunction with fluoride on plasma and tissue acetylcholinesterase (AChE) activity in wistar rats. Fluoride at 1 or 10 ppm in drinking water produced significant (P < 0.05)
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[Effects of sodium fluoride on the activity of Ca2+Mg(2+)-ATPase in synaptic membrane in rat brain].
Effects of sodium fluoride on Ca2+Mg(2+)-ATPase activity of synaptic membrane in rat brain were studied with in vitro or in vivo methods. Concentrations of sodium fluoride of 0.3, 1.6, 8.0, 20.0 and 40.0 mmol/L can significantly inhibit the activity of the enzyme with proportions of 6.6%, 18.0%, 41.0%, 55.5% and
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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Fluoride & IQ: 69 Studies
As of June 2021, a total of 77 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 69 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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