Abstract

Kittens were fed fluoride (2.5 mg. per kilogram of body weight) for 2 months. In one group of animals the addition of calcium (20 mg. per kilogram) to an otherwise calcium-deficient diet resulted in a depressed serum calcium, abnormally wide osteroid tissue, and increased formation and resorption of bone. In a second group, the addition of calcium (100 mg. per kilogram) to the diet prevented the decrease in serum calcium and the development of wide osteoid borders, and it reduced both the resorption and, to a lesser extent, the formation of bone tissue. The study shows that elevated levels of calcium in the diet are capable of preventing the osteomalacic effects of high levels of fluoride.

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