Abstract
The present study investigates the effect of the Sodium Fluoride (NaF) on Wistar Albino mice. The animals have been divided into three batches each containing five individuals among which 1 batch served as control while, remaining two batches were treated with 5 and 10ppm respectively. After completion of exposure, the animals were subjected to behavioural studies. Then the animals were sacrificed and the brain regions were used for the biochemical analysis. Significant behavioral changes were observed in the NaF treated animals when compared to the control animals. Among the two doses the animals exposed to high dose showed significant changes compared to low dose exposed animals. Among the biochemical parameters studied AChE activity was decreased in the brain region of the animals exposed to NaF compared to the control. Besides decrease in AChE activity, ACh content was found to be increased in the brain regions of the NaF exposed animals. Among the different brain regions studied Cerebral Cortex was found to be more vulnerable to the NaF toxicity. However 10pm NaF showed more inhibition both in terms of behavioral and biochemical alterations in the Mice compared to the 5ppm exposed animals.
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Interplay of ROS and behavioral pattern in fluoride exposed Drosophila melanogaster.
Highlights NaF exposure increases mortality and changes male-female ratio in Drosophila. NaF treatment alters the activities endogenous antioxidant enzymes. Chronic sub-lethal NaF exposure causes increased oxidative damage. NaF decreases brain cell viability and increases DNA damage. NaF exposure alters selected behavioral pattern in Drosophila melanogaster. Reactive oxygen species (ROS) is
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Effects of sodium fluoride on locomotor behavior and a few biochemical parameters in rats
Spontaneous motor activity and motor coordination were tested in adult female rats after treating with sodium fluoride at 20 or 40 mg/kg dose level daily for 60 days, using an activity chamber and a rota-rod apparatus, respectively. Total protein concentrations were determined in skeletal muscle, liver and serum of similarly
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Neurobehavioral and neurochemical effects in rats offspring co-exposed to arsenic and fluoride during development.
Highlights Arsenic/Fluoride co-exposure during development causes neurobehavioral alterations in offspring. iAs/F causes delayed development of sensorimotor reflexes and produces less nociceptive response. iAs/F co-exposure increase locomotor activity. Antioxidant enzymes and neurotransmitter level are altered in the striatum area. Arsenic (iAs) and fluoride (F) are ubiquitous in the environment. All over
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Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats
Spontaneous motor activity, rota-rod performance (motor co-ordination), body weight gain, food intake, activities of total cholinesterase (blood) and acetylcholinesterase (brain), and dental structure were determined in adult female rats treated with a very high dose of sodium fluoride (500 ppm in drinking water) alone and in combination with calcium carbonate
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Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats.
Highlights The influence of rutin on fluoride – induced neurotoxicity in rat was studied. Rutin reversed the fluoride – induced neurobehavioral deficits in rats. Rutin reversed the fluoride – induced inhibition of acetylcholinesterase activity in rat cerebrum and striatum. Rutin enhanced antioxidant status and inhibited neuro-inflammation and apoptosis in fluoride
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