Abstract

The present study investigates the effect of the Sodium Fluoride (NaF) on Wistar Albino mice. The animals have been divided into three batches each containing five individuals among which 1 batch served as control while, remaining two batches were treated with 5 and 10ppm respectively. After completion of exposure, the animals were subjected to behavioural studies. Then the animals were sacrificed and the brain regions were used for the biochemical analysis. Significant behavioral changes were observed in the NaF treated animals when compared to the control animals. Among the two doses the animals exposed to high dose showed significant changes compared to low dose exposed animals. Among the biochemical parameters studied AChE activity was decreased in the brain region of the animals exposed to NaF compared to the control. Besides decrease in AChE activity, ACh content was found to be increased in the brain regions of the NaF exposed animals. Among the different brain regions studied Cerebral Cortex was found to be more vulnerable to the NaF toxicity. However 10pm NaF showed more inhibition both in terms of behavioral and biochemical alterations in the Mice compared to the 5ppm exposed animals.

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