Fluoride Action Network


The influence of chronic Fl intoxication on lipid peroxidation and the state of the antioxidant system was studied in rats on different diets. Chronic Fl intoxication inhibited antioxidant activity and caused an increase in the rate of peroxidation and the level of lipoperoxides in liver, brain and serum. Diets with enriched fat aggravated these disturbances; diets rich in protein had a beneficial effect. Additional complex supplementation of protein with Met and vitamin E restored original antioxidant activity and reduced the content of lipoperoxides in tissues almost to the normal level and was recommended as protecting factors in fluorosis.