Abstract
1) The low incidence of dental caries observed in mongoloid patients led to an investigation of the role of fluorine in this condition.
2) A statistical study of the geographical distribution of mongolism in Wisconsin, Illinois, Idaho, North and South Dakota (U.S.A.) shows a parallelism between the prevalence of this condition and the amount of fluoride in the water supply.
3) A new hypothesis on the pathogenesis of mongolism is proposed: the blockage of an enzymatic system by an inhibitor, such as fluorine, at an early stage of the fetal development.
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Editorial review: Fluoride and down's syndrome (mongolism)
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Oligophrenie mongolienee et caries dentaires
Une enquête épidémiologique sur la fréquence du mongolisme dans quelques Etats du Midwest américain nous a permis de mettre en évidence les faits suivants: 1: un parallélisme entre la fréquence du mongolisme et la teneur en fluor de l'eau de boisson; 2: une rareté relative des caries dentaires chez les mongoliens; 3: une
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[New researches on mongolism related to the disease producing role of fluorine].
A new statistical study on the distribution of mongolism in cities in Illinois, United States, from January 1, 1950 to December 31, 1956, permits us to verify an increasing frequency of this affliction associated with the concentration of fluorine in the drinking water. This study follows a preceding inquiry on the
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Fluoridation and the occurrence of Down's syndrome
The prevalence rates of Down's syndrome at birth were compared for Massachusetts residents ingesting fluoridated and non-fluoridated water. The observations included nearly all children born alive with Down's syndrome in Massachusetts during the 17-year period 1950-1966. A rate of 1.5 cases per 1000 births was found for fluoride-related births and
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Sodium fluoride disrupts DNA methylation of H19 and Peg3 imprinted genes during the early development of mouse embryo
Sodium fluoride (NaF) is associated with embryonic and fetal development abnormalities, but the mechanism by which this occurs is unclear. DNA methylation, an important epigenetic reprogramming mechanism, is essential for normal embryonic development. Thus, we investigated the effect of NaF on DNA methylation in early mouse embryos, as well as
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