Abstract
A new statistical study on the distribution of mongolism in cities in Illinois, United States, from January 1, 1950 to December 31, 1956, permits us to verify an increasing frequency of this affliction associated with the concentration of fluorine in the drinking water.
This study follows a preceding inquiry on the prevalence of cases of mongolism born before 1950 in the same state.
Such inquiries should not be conducted in other countries without an evaluation of the contribution of fluorine from diet which varies from country to country.
The role of the advanced age of the mother, in the etiology of mongolism, would seem to reflect a slow and progressive accumulation of fluorine in the mother’s body.
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Role des inhibiteurs enzymatiques dans l'etiologie du mongolisme
1) The low incidence of dental caries observed in mongoloid patients led to an investigation of the role of fluorine in this condition. 2) A statistical study of the geographical distribution of mongolism in Wisconsin, Illinois, Idaho, North and South Dakota (U.S.A.) shows a parallelism between the prevalence of this condition
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Editorial review: Fluoride and down's syndrome (mongolism)
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Oligophrenie mongolienee et caries dentaires
Une enquête épidémiologique sur la fréquence du mongolisme dans quelques Etats du Midwest américain nous a permis de mettre en évidence les faits suivants: 1: un parallélisme entre la fréquence du mongolisme et la teneur en fluor de l'eau de boisson; 2: une rareté relative des caries dentaires chez les mongoliens; 3: une
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Sodium fluoride disrupts DNA methylation of H19 and Peg3 imprinted genes during the early development of mouse embryo
Sodium fluoride (NaF) is associated with embryonic and fetal development abnormalities, but the mechanism by which this occurs is unclear. DNA methylation, an important epigenetic reprogramming mechanism, is essential for normal embryonic development. Thus, we investigated the effect of NaF on DNA methylation in early mouse embryos, as well as
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Fluoridation and the occurrence of Down's syndrome
The prevalence rates of Down's syndrome at birth were compared for Massachusetts residents ingesting fluoridated and non-fluoridated water. The observations included nearly all children born alive with Down's syndrome in Massachusetts during the 17-year period 1950-1966. A rate of 1.5 cases per 1000 births was found for fluoride-related births and
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