Abstract
Une enquête épidémiologique sur la fréquence du mongolisme dans quelques Etats du Midwest américain nous a permis de mettre en évidence les faits suivants:
1: un parallélisme entre la fréquence du mongolisme et la teneur en fluor de l’eau de boisson;
2: une rareté relative des caries dentaires chez les mongoliens;
3: une concentration en fluor des dents, relativement plus élevée chez les mongoliens;
4: l’apparition d’une grande fréquence de tumeurs mélaniques chez la Drosophile, sous l’action du fluor, ce qui traduit des modifications du métabolisme du tryptophane, similaires aux déviations métaboliques, génétiquement contrôlées, mises en évidence chez les mongoliens.
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[New researches on mongolism related to the disease producing role of fluorine].
A new statistical study on the distribution of mongolism in cities in Illinois, United States, from January 1, 1950 to December 31, 1956, permits us to verify an increasing frequency of this affliction associated with the concentration of fluorine in the drinking water. This study follows a preceding inquiry on the
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Role des inhibiteurs enzymatiques dans l'etiologie du mongolisme
1) The low incidence of dental caries observed in mongoloid patients led to an investigation of the role of fluorine in this condition. 2) A statistical study of the geographical distribution of mongolism in Wisconsin, Illinois, Idaho, North and South Dakota (U.S.A.) shows a parallelism between the prevalence of this condition
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Editorial review: Fluoride and down's syndrome (mongolism)
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Sodium fluoride as potential mutagen in mammalian eggs
Evidence from other forms demonstrating mitotic chromosome damage has suggested that sodium fluoride (NaF), a primary air pollutant, be explored as a mutagenic compound in female mammalian germ cells. In vitro experiments with mouse, sheep, and cow oocytes have disclosed a low incidence of anaphase lags, suppression of polar body
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Association of Down's syndrome and water fluoride level: a systematic review of the evidence
Background: A review of the safety and efficacy of drinking water fluoridation was commissioned by the UK Department of Health to investigate whether the evidence supported a beneficial effect of water fluoridation and whether there was any evidence of adverse effects. Down's syndrome was one of the adverse effects reported. The
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