Abstract
1. A comparison was made of the effect of fluorine ingested by. rats from drinking water in the form of sodium fluoride vs. sodium fluosilicate; the quantity of fluorine equaled 5, 10, 15, 25, and 50 p.p.m.
2. No differences were observed in the quantity of fluorine deposited in the incisor and molar teeth, mandibles, and femurs, nor in the percent of the ingested fluorine which was retained in the rat’s body. There was no difference in the ash, calcium, and phosphorus content of the incisor teeth, molar teeth, mandibles, and femurs which could be related to the kind of fluoride ingested.
3. There were no differences in the appearance of the characteristic striations on the rats’ incisor teeth which could be attributed to the sodium fluoride vs. sodium fluosilicate.
4. The presence of 15 p.p.m. of silicon as sodium silicate along with 25 p.p.m. of fluorine as sodium fluoride did not affect the amount of fluorine deposited in the rat’s body.
5. The rate of growth was normal in all groups of rats.
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Pharmacokinetics of ingested fluoride: lack of effect of chemical compound
Fluoride in drinking water may be present from natural sources or added as sodium fluoride (NaF), sodium silicofluoride (Na(2)SiF(6)) or fluorosilicic acid (H(2)SiF(6)). Results from an early study with rats suggested that, when ingested as Na(2)SiF(6), the absorption and excretion of fluoride were greater than when ingested as NaF. OBJECTIVE: The
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The fractional urinary fluoride excretion of adults consuming naturally and artificially fluoridated water and the influence of water hardness: a randomized trial
AIMS: To assess whether there was any significant difference in the average fractional urinary fluoride excretion (FUFE) values among adults consuming (NaF) fluoridated Ca-free water (reference water), naturally fluoridated hard water and an artificially (H2SiF6) fluoridated soft water. DESIGN: Sixty adult females (N=20 for each treatment) participated in this randomized, double-blind
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Fluoride increases lead concentrations in whole blood and in calcified tissues from lead-exposed rats
Higher blood lead (BPb) levels have been reported in children living in communities that receive fluoride-treated water. Here, we examined whether fluoride co-administered with lead increases BPb and lead concentrations in calcified tissues in Wistar rats exposed to this metal from the beginning of gestation. We exposed female rats and
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Bioavailability of fluoride in drinking water: a human experimental study
It has been suggested that systemic fluoride absorption from drinking water may be influenced by the type of fluoride compound in the water and by water hardness. Using a human double-blind cross-over trial, we conducted this study to measure c(max), T(max), and Area Under the Curve (AUC) for plasma F
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Physiologic conditions affect toxicity of ingested industrial fluoride
The effects of calcium ion and broad pH ranges on free fluoride ion aqueous concentrations were measured directly and computed theoretically. Solubility calculations indicate that blood fluoride concentrations that occur in lethal poisonings would decrease calcium below prevailing levels. Acute lethal poisoning and also many of the chronic effects of
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Westendorf's Research on Incomplete Dissociation of Silicofluorides Under Physiological Conditions
The Kinetics of Acetylcholinesterase Inhibition and the Influence of Fluoride and Fluoride Complexes on the Permeability of Erythrocyte Membranes Dissertation to receive Ph.D. in Chemistry from the University of Hamburg By Johannes Westendorf Hamburg, Germany - 1975 (Click here to read Westendorf's thesis) Reviewer: Prof Dr. A. Knappwost Co-Reviewers: Prof, Dr, Malomy Prof, DR, Strehlow Prof, Dr. Hilz Prof Dr. Gercken The
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Fluorine recovery in the fertilizer industry - a review.
The fluorine compounds liberated during the acidulation of phosphate rock in the manufacture of phosphoric acid and fertilizers are now rightly regarded as a menace, and the industry is now obliged to suppress emissions of fluorine-containing vapours to within very low limits in most parts of the world. As with any pollution control operation, it is highly desirable for the operator of the fluorine scrubbing operation to find a use or market for the recovered fluorine to help defray at least partially the cost of the operation.
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