Abstract
Fluoride is widely used for the prevention of dental caries. Very low concentrations of fluoride are routinely ingested in optimally fluoridated drinking water of many communities. Higher concentrations of fluoride in toothpastes, mouthrinses and topically applied gels also may be ingested, especially by children. The potential effect of ingested fluoride on the gastric mucosa was the subject of this investigation. Solutions of 0, 1, or 10 mM NaF in 0.1 N HCl were placed in rat stomachs in vivo for up to one hour. The effects of fluoride on the structure and function of the gastric mucosa were determined. Histologic and SEM examinations revealed dose- and time-dependent damage to the surface mucous cells. The 10 mM, but not the 1 mM, NaF solution increased gastric mucosal permeability to small but not to large molecules.
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Prenatal and postnatal ingestion of fluoride salts: a progress report.
Undesirable Effects Out of the 601 cases in the adult group, six have shown undesirable side effects from the fluoride supplement. Five out of the 495 children have presented evidence of undesirable reactions. This is 1 per cent incidence of side effects. Reactions in Adults - Included in the adult cases are
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Effect of sodium fluoride on gastric emptying and intestinal transit in mice
Fluoride, a well-recognised harmful substance, is easily absorbed by the gastrointestinal mucosa. It is therefore conceivable that any alteration of the gastrointestinal motility can affect the rate of absorption of fluoride and leads to aggravation of its toxic effects. The effects of fluoride on gastric emptying and intestinal transit were
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A double blind test for determination of intolerance to fluoridated water (preliminary report).
A double blind test for the detection of untoward effects from fluoridated water is described. Preliminary results with 60 patients out of a group of 300 indicate that certain individuals are intolerant to fluoride and reproducibly develop gastrointestinal symptoms, stomatitis, joint pains, polydipsia, headaches, and visual disturbances.
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Toxicology and Carcinogenesis Studies of Sodium Fluoride in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
CASRN: 7681-49-4 Chemical Formula: NaF Molecular Weight: 41.99 Report Date: December 1990 Sodium fluoride is a white, crystalline, water-soluble powder used in municipal water fluoridation systems, in various dental products, and in a variety of industrial applications. Toxicology and carcinogenesis studies were conducted with F344/N rats and B6C3F1 mice of each sex by incorporating
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Gastric ulcer and fluoride
Czerwinski and Lankosz reported that 7 out of 60 retired workers (12%) in a Polish aluminum plant, who showed evidence of low-grade skeletal fluorosis, were afflicted with gastric ulcer. Such a high incidence raises the question whether or not certain kinds of ulcers in the stomach and upper intestinal tract
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Fluoride-Induced Damage to Gastric Mucosa in Human Clinical Trials
When fluoride has been used (at doses of 18-34 mg/day) as an experimental treatment for osteoporosis, gastric pain is one of the two main side effects consistently encountered. To better understand how fluoride causes this effect, researchers have sought to determine how fluoride affects the tissue that lines the gastrointestinal tract. In a
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Side Effects from Fluoride Gels: Gastric Distress
Gastric distress -- including nausea, pain, and vomiting -- is one the most common side effects from professional application of "fluoride gels" at the dentist. Patients receiving fluoride gels can swallow more than 20 mg of fluoride from a single treatment -- doses that far exceed the doses that can
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Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach
The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The
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Fluoride-Induced Gastric Symptoms in Human Clinical Trials
In studies where fluoride has been used (at doses of 18-34 mg/day) as an experimental drug for the treatment of osteoporosis, gastrointestinal disturbances are one of the two main side effects consistently encountered. The following are some of the accounts from the published literature: "The use of fluoride in the prophylaxis or
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Gastrointestinal Problems Among Individuals with Skeletal Fluorosis
Humans suffering from skeletal fluorosis are known to suffer from an increased occurrence of gastrointestinal disorders. When fluoride intake is reduced, these gastrointestinal problems are among the first symptoms to disappear. The following are some of the studies that have examined this issue: "It is clear from the observations presented in this article
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