Abstract
The effects of sodium-fluoride (7681494) on gastric secretion were studied in rats. Male albino-rats were administered 25 milligrams per kilogram sodium-fluoride in their drinking water for 60 days. Selected rats were killed after 7, 15, 30, and 60 days, and stomachs were dissected out, the gastric juice collected, and the volume recorded. After centrifugation to remove suspended food particles, the gastric juice was analyzed for free and total acidity. Peptic activity was determined. Gastric volume was significantly increased after 30 and 69 days of sodium-fluoride treatment. Total acidity increased progressively with duration of treatment. Free acidity was significantly increased after 30 and 60 days. The increase in total acidity at 30 and 60 days was mainly due to the increase in free acidity. Peptic acidity was increased at all time points in treated animals, with the greatest increases occurring after 30 and 60 days. The authors suggest that elevation of cyclic-adenosine-monophosphate concentrations in the stomach by sodium-fluoride can stimulate hydrogen ion output. This could explain the gastric symptoms of individuals in endemic fluorosis areas and workers exposed to air contaminants containing fluoride.
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Suppressive effects of dietary high fluorine on the intestinal development in broilers
Fluoride (F) is a well-recognized hazardous substance. Ingested F initially acts locally on the intestines. The small intestine plays a critical role in the digestion, absorption, and defense. In this study, therefore, we investigated the effects of fluorine on the intestinal development by light microscopy, transmission electron microscopy, and histochemistry.
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Fluoride induced leaky gut and bloom of Erysipelatoclostridium ramosum mediate the exacerbation of obesity in high-fat-diet fed mice.
Introduction Fluoride is widely presented in drinking water and foods. A strong relation between fluoride exposure and obesity has been reported. However, the potential mechanisms on fluoride-induced obesity remain unexplored. Objectives and methods The effects of fluoride on the obesity were investigated using mice model. Furthermore, the role of gut homeostasis in exacerbation
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Preventive effects of Lactobacillus johnsonii on the renal injury of mice induced by high fluoride exposure: Insights from colonic microbiota and co-occurrence network analysis.
Highlights L. johnsonii BS15 could protects the kidney tissue from renal lesion and dysfunction induced by high fluoride exposure. Colonic microbial structure and diversity was significantly altered by fluoride exposure and probiotic treatment. Fluoride- and probiotic-altered sensitive and well-connected species may be closely related to renal health. Fluoride (F) exposure
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Fluoride disrupts intestinal epithelial tight junction integrity through intracellular calcium-mediated RhoA/ROCK signaling and myosin light chain kinase
Highlights Fluoride increases epithelial intestinal barrier permeability. Fluoride induces the downregulation and redistribution of ZO-1. Fluoride releases intracellular calcium ions to activate RhoA/ROCK pathway and MLCK. RhoA/ROCK pathway and MLCK play essential roles in fluoride-triggered MLC2 phosphorylation and F-actin rearrangement. Fluoride is a common contaminant of groundwater and agricultural commodity, which
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Haematological changes in fluorotic adults and children in fluoride endemic regions of Gaya district, Bihar, India.
Groundwater used for drinking and cooking was analysed for fluoride (F), and health surveys were conducted in Bodh Gaya, Amas and Bankebazaar blocks of the Gaya district, Bihar, India. Amas and Bankebazaar blocks were F endemic areas with mean F = 2.36 ± 0.23 mg/L (N = 27). Bodh Gaya was considered as control area with
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Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach
The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The
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Side Effects from Fluoride Gels: Gastric Distress
Gastric distress -- including nausea, pain, and vomiting -- is one the most common side effects from professional application of "fluoride gels" at the dentist. Patients receiving fluoride gels can swallow more than 20 mg of fluoride from a single treatment -- doses that far exceed the doses that can
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Fluoride-Induced Damage to Gastric Mucosa in Human Clinical Trials
When fluoride has been used (at doses of 18-34 mg/day) as an experimental treatment for osteoporosis, gastric pain is one of the two main side effects consistently encountered. To better understand how fluoride causes this effect, researchers have sought to determine how fluoride affects the tissue that lines the gastrointestinal tract. In a
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Fluoride-Induced Gastric Symptoms in Human Clinical Trials
In studies where fluoride has been used (at doses of 18-34 mg/day) as an experimental drug for the treatment of osteoporosis, gastrointestinal disturbances are one of the two main side effects consistently encountered. The following are some of the accounts from the published literature: "The use of fluoride in the prophylaxis or
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Gastrointestinal Problems Among Individuals with Skeletal Fluorosis
Humans suffering from skeletal fluorosis are known to suffer from an increased occurrence of gastrointestinal disorders. When fluoride intake is reduced, these gastrointestinal problems are among the first symptoms to disappear. The following are some of the studies that have examined this issue: "It is clear from the observations presented in this article
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