Abstract
To gain a better understanding of how fluoride causes gastrointestinal distress, we conducted an experimental study on rabbits to evaluate damage to the gastroduodenal tissue by sodium fluoride. Young albino rabbits weighing 400-600 g were injected daily with 5, 10, 20, and 50 mg NaF/kg bw for fifteen weeks and then sacrificed. Histopathological examination of the duodenum revealed erosion and necrosis of surface mucosa, hemorrhages, necrosis of Brunner’s gland, clumped submucosa, and hypertrophy of muscles in muscularis mucosae in increasing severity according to the dose of NaF. Most noteworthy was the loss of mucosal layer in direct proportional to the amount of fluoride administered.
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Probiotic alleviate fluoride-induced memory impairment by reconstructing gut microbiota in mice.
Highlights Memory function was reduced in the fluoride-exposed mice. Gut microbiota structure in fluoride-exposed mice was significantly altered. Lactobacillus was the mainly targeting bacteria in fluoride-treated mice. Inoculation with Lactobacillus johnsonii reconstructed gut microbiota in fluoride-exposed mice. Inoculation with Lactobacillus johnsonii rescued memory dysfunction in fluoride-expose mice. Fluoride which is
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Toxicology and Carcinogenesis Studies of Sodium Fluoride in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
CASRN: 7681-49-4 Chemical Formula: NaF Molecular Weight: 41.99 Report Date: December 1990 Sodium fluoride is a white, crystalline, water-soluble powder used in municipal water fluoridation systems, in various dental products, and in a variety of industrial applications. Toxicology and carcinogenesis studies were conducted with F344/N rats and B6C3F1 mice of each sex by incorporating
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Effect of Fluoride in Drinking Water on Fecal Microbial Community in Rats.
Intestinal nutrition has a close association with the onset and development of fluorosis. Intestinal microbes play a major role in intestinal nutrition. However, the effect of fluoride on intestinal microbes is still not fully understood. This study aimed to evaluate the dose-response of fluoride on fecal microbes as well as
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Effect of sodium fluoride on gastric emptying and intestinal transit in mice
Fluoride, a well-recognised harmful substance, is easily absorbed by the gastrointestinal mucosa. It is therefore conceivable that any alteration of the gastrointestinal motility can affect the rate of absorption of fluoride and leads to aggravation of its toxic effects. The effects of fluoride on gastric emptying and intestinal transit were
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Clinical features of early stages of occupational fluorosis under the combined and joint effect of production factors
Over 1000 workers of hydrofluoric and cryolite enterprises and electrolysis shops of aluminium enterprises were examined. Subjects exposed to soluble hydrofluorides presented in the early stage of chronic intoxication with a variety of syndromes, that was characteristic of intoxication with poisons of general toxic action with involvement of hepatobiliary, digestive,
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Fluoride-Induced Gastric Symptoms in Human Clinical Trials
In studies where fluoride has been used (at doses of 18-34 mg/day) as an experimental drug for the treatment of osteoporosis, gastrointestinal disturbances are one of the two main side effects consistently encountered. The following are some of the accounts from the published literature: "The use of fluoride in the prophylaxis or
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Side Effects from Fluoride Gels: Gastric Distress
Gastric distress -- including nausea, pain, and vomiting -- is one the most common side effects from professional application of "fluoride gels" at the dentist. Patients receiving fluoride gels can swallow more than 20 mg of fluoride from a single treatment -- doses that far exceed the doses that can
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Gastrointestinal Problems Among Individuals with Skeletal Fluorosis
Humans suffering from skeletal fluorosis are known to suffer from an increased occurrence of gastrointestinal disorders. When fluoride intake is reduced, these gastrointestinal problems are among the first symptoms to disappear. The following are some of the studies that have examined this issue: "It is clear from the observations presented in this article
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Fluoride-Induced Damage to Gastric Mucosa in Human Clinical Trials
When fluoride has been used (at doses of 18-34 mg/day) as an experimental treatment for osteoporosis, gastric pain is one of the two main side effects consistently encountered. To better understand how fluoride causes this effect, researchers have sought to determine how fluoride affects the tissue that lines the gastrointestinal tract. In a
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Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach
The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The
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