Abstract
To gain a better understanding of how fluoride causes gastrointestinal distress, we conducted an experimental study on rabbits to evaluate damage to the gastroduodenal tissue by sodium fluoride. Young albino rabbits weighing 400-600 g were injected daily with 5, 10, 20, and 50 mg NaF/kg bw for fifteen weeks and then sacrificed. Histopathological examination of the duodenum revealed erosion and necrosis of surface mucosa, hemorrhages, necrosis of Brunner’s gland, clumped submucosa, and hypertrophy of muscles in muscularis mucosae in increasing severity according to the dose of NaF. Most noteworthy was the loss of mucosal layer in direct proportional to the amount of fluoride administered.
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Exposure to fluoride in smelter workers in a primary aluminum industry in India
BACKGROUND: Fluoride is used increasingly in a variety of industries in India. Emission of fluoride dust and fumes from the smelters of primary aluminum producing industries is dissipated in the work environment and poses occupational health hazards. OBJECTIVE: To study the prevalence of health complaints and its association with fluoride level
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In-depth insights into the disruption of the microbiota-gut-blood barrier of model organism (Bombyx mori) by fluoride.
Highlights Fluoride impairs the intestinal epithelial cells of the host. The intestinal microbiota structure of the host organism is altered by fluoride. Amino acid and nucleotide metabolisms are perturbed by extreme fluoride intake. Supplementary probiotics is a potential preventive therapy for host fluorosis. Fluoride disrupts the microbiota-gut-blood barrier functions
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Fluoride in Drinking Water: A Scientific Review of EPA’s Standards.
Excerpts: Summary Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might cause any adverse effects on human health. These standards include the maximum contaminant level goal (MCLG), the maximum contaminant level (MCL), and the secondary
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Massive fluorosis of bones and ligaments
Summary The authors record the results of their clinical examination of 78 workers engaged in the crushing and refining of cryolite. Beside silicosis -- to as much as the second degree -- which was present in 39, the following three diseases were found to be common in these workers: 1) a curious
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Tissue response of gastric mucosa after ingestion of fluoride
Fluoride has been used successfully to prevent dental caries and has also been used to treat osteoporosis. Doses of sodium fluoride of about 50 mg a day have long term beneficial effects on the mineral content of bone and the incidence of fracture. (1) These doses, however, have resulted in
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Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach
The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The
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Fluoride-Induced Gastric Symptoms in Human Clinical Trials
In studies where fluoride has been used (at doses of 18-34 mg/day) as an experimental drug for the treatment of osteoporosis, gastrointestinal disturbances are one of the two main side effects consistently encountered. The following are some of the accounts from the published literature: "The use of fluoride in the prophylaxis or
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Fluoride-Induced Damage to Gastric Mucosa in Human Clinical Trials
When fluoride has been used (at doses of 18-34 mg/day) as an experimental treatment for osteoporosis, gastric pain is one of the two main side effects consistently encountered. To better understand how fluoride causes this effect, researchers have sought to determine how fluoride affects the tissue that lines the gastrointestinal tract. In a
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Side Effects from Fluoride Gels: Gastric Distress
Gastric distress -- including nausea, pain, and vomiting -- is one the most common side effects from professional application of "fluoride gels" at the dentist. Patients receiving fluoride gels can swallow more than 20 mg of fluoride from a single treatment -- doses that far exceed the doses that can
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Gastrointestinal Problems Among Individuals with Skeletal Fluorosis
Humans suffering from skeletal fluorosis are known to suffer from an increased occurrence of gastrointestinal disorders. When fluoride intake is reduced, these gastrointestinal problems are among the first symptoms to disappear. The following are some of the studies that have examined this issue: "It is clear from the observations presented in this article
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