Abstract
Czerwinski and Lankosz reported that 7 out of 60 retired workers (12%) in a Polish aluminum plant, who showed evidence of low-grade skeletal fluorosis, were afflicted with gastric ulcer. Such a high incidence raises the question whether or not certain kinds of ulcers in the stomach and upper intestinal tract might be related to F-. The daily diet contains F-. A cardinal feature of acute poisoning from inorganic fluoride compounds is severe vomiting, extreme pain in the epigastrium and gastric hemorrhages. At autopsy, ulcerations of the stomach and the upper intestinal tract are almost always present. The degree of damage to the gastric mucosa, i.e., the severity of the ulceration, is dependent on the amount of the fluoride compound ingested, the tightness of the bond of the F- in the molecule of the compound and the acidity of the stomach of the individual patient.
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Fluoride-related bone disease associated with habitual tea consumption
Acquired osteosclerosis is a rare disorder of bone formation but an important consideration in adults with sclerotic bones or elevated bone density results. In such patients, malignancy, hepatitis C, and fluorosis should all be considered when making a diagnosis. We describe 4 patients evaluated at our Metabolic Bone Disease Clinic
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Fluorine Intoxication: A Clinical-Hygienic Study with a Review of the Literature and Some Experimental Investigations
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Dyspepsia associated with fluoridated water
The case is presented of 77-year-old woman with a ten-year history of weight loss, dyspepsia, and gastric ulcer resistant to medical management. Within two weeks after she began using a reverse osmosis (RO) unit on her municipal fluoridated (0.85–1.0 ppm F) drinking water source and, without further medication, the patient gained almost full recovery.
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Prevalence of endemic fluorosis with gastrointestinal manifestations in people living in some North-Indian villages
Numerous reports on epidemiological surveys of skeletal and dental fluorosis exist, but information is quite limited on non-skeletal manifestations of fluoride toxicity. The present study was conducted to assess the prevalence and severity of non-skeletal manifestations, especially gastrointestinal disturbances, in an area o skeletal and dental fluorosis. The subjects, numbering 1958
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Alteration in gastric secretion of rats administered NaF
The effects of sodium-fluoride (7681494) on gastric secretion were studied in rats. Male albino-rats were administered 25 milligrams per kilogram sodium-fluoride in their drinking water for 60 days. Selected rats were killed after 7, 15, 30, and 60 days, and stomachs were dissected out, the gastric juice collected, and the
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Gastrointestinal Problems Among Individuals with Skeletal Fluorosis
Humans suffering from skeletal fluorosis are known to suffer from an increased occurrence of gastrointestinal disorders. When fluoride intake is reduced, these gastrointestinal problems are among the first symptoms to disappear. The following are some of the studies that have examined this issue: "It is clear from the observations presented in this article
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Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach
The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The
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Side Effects from Fluoride Gels: Gastric Distress
Gastric distress -- including nausea, pain, and vomiting -- is one the most common side effects from professional application of "fluoride gels" at the dentist. Patients receiving fluoride gels can swallow more than 20 mg of fluoride from a single treatment -- doses that far exceed the doses that can
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Fluoride-Induced Gastric Symptoms in Human Clinical Trials
In studies where fluoride has been used (at doses of 18-34 mg/day) as an experimental drug for the treatment of osteoporosis, gastrointestinal disturbances are one of the two main side effects consistently encountered. The following are some of the accounts from the published literature: "The use of fluoride in the prophylaxis or
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Fluoride-Induced Damage to Gastric Mucosa in Human Clinical Trials
When fluoride has been used (at doses of 18-34 mg/day) as an experimental treatment for osteoporosis, gastric pain is one of the two main side effects consistently encountered. To better understand how fluoride causes this effect, researchers have sought to determine how fluoride affects the tissue that lines the gastrointestinal tract. In a
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