Topical fluorides: effects on physiologic and biochemical processes

The ingestion of fluoride from dentifrices or mouthrinses can contribute substantially to the total daily intake of the ion, even in communities that provide optimally fluoridated drinking water. It is concluded that the frequent and unsupervised use of these products by children six years of age or younger, especially those living in

Gastric discomforts from fluoride in drinking water in Sanganer Tehsil, Rajasthan, India

A health survey of 1135 children and 1475 adults living in Sanganer Tehsil, Rajasthan, India, revealed a wide range of gastrointestinal (GI) discomforts associated with fluoride (F) in the groundwater in over 30 village areas. Complaints of abdominal pain including stomach ache, a bloated feeling, nausea, diarrhea, and constipation were

Effect of Fluoride on Small Intestine Morphology and Serum Cytokine Contents in Rats.

This study aimed to determine the effect of excessive fluoride (F) on the morphological characteristics of the small intestine and the contents of serum cytokines in rats. A total of 48 3-week-old healthy female Sprague-Dawley rats were randomly divided into four groups (n?=?12). The control group was given deionized distilled

Suppressive effects of dietary high fluorine on the intestinal development in broilers

Fluoride (F) is a well-recognized hazardous substance. Ingested F initially acts locally on the intestines. The small intestine plays a critical role in the digestion, absorption, and defense. In this study, therefore, we investigated the effects of fluorine on the intestinal development by light microscopy, transmission electron microscopy, and histochemistry.

Fluorine Intoxication: A Clinical-Hygienic Study with a Review of the Literature and Some Experimental Investigations

Fluoride-Induced Damage to Gastric Mucosa in Human Clinical Trials

When fluoride has been used (at doses of 18-34 mg/day) as an experimental treatment for osteoporosis, gastric pain is one of the two main side effects consistently encountered. To better understand how fluoride causes this effect, researchers have sought to determine how fluoride affects the tissue that lines the gastrointestinal tract. In a

Side Effects from Fluoride Gels: Gastric Distress

Gastric distress -- including nausea, pain, and vomiting -- is one the most common side effects from professional application of "fluoride gels" at the dentist. Patients receiving fluoride gels can swallow more than 20 mg of fluoride from a single treatment -- doses that far exceed the doses that can

Fluoride-Induced Gastric Symptoms in Human Clinical Trials

In studies where fluoride has been used (at doses of 18-34 mg/day) as an experimental drug for the treatment of osteoporosis, gastrointestinal disturbances are one of the two main side effects consistently encountered. The following are some of the accounts from the published literature: "The use of fluoride in the prophylaxis or

Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach

The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The

Gastrointestinal Problems Among Individuals with Skeletal Fluorosis

Humans suffering from skeletal fluorosis are known to suffer from an increased occurrence of gastrointestinal disorders. When fluoride intake is reduced, these gastrointestinal problems are among the first symptoms to disappear. The following are some of the studies that have examined this issue: "It is clear from the observations presented in this article