Abstract

The aim of this study was to evaluate the effects of fluoride on anxiety and depression in mice. Control and study groups were formed with ten 4-month-old male Swiss mice in each group. For 90 days, mice in the control group were given drinking water containing 0.3 ppm fluoride while the study group was given water with 40 ppm fluoride. Tail suspension was not significantly different between the study and the control groups. In an open field test, however, the number of defecations was higher in the study group, and transitions, rearing, and grooming activities were less frequent. Under these conditions, fluoride appeared to have no antidepressant effect in mice but rather an anxiety stimulating effect.

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