Abstract
To investigate effects of sodium fluoride (NaF) on the cerebellum cerebral hemisphere brain of rats and its possible amelioration by the popular Ayurvedic herbal health product triphala, adult female Wistar rats (Rattus novergicus) were administered 10 mg NaF/kg bw/day and 30 mg triphala/kg bw/day for 30 days. A significant decline in body and brain tissue weights after NaF treatment was noted. The decreased succinate dehydrogenase (SDH) activity indicated an alteration in mitochondrial structure and function by fluoride poisoning affecting energy metabolism. An increase in the total lipid could be the result of the inhibition of enzymes and reduction of fatty acid synthesis. Moreover, increased lipid peroxidation indicated an oxidative stress in the brain. These effects were correlated with histological changes and accumulation of fluoride in the neural tissue. However, these changes were ameliorated by co-supplementation of triphala with NaF. The antioxidant properties of the herbal product triphala therefore had an alleviating effect on NaF-induced neurotoxicity in rats.
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Protective role of gallic acid on sodium fluoride induced oxidative stress in rat brain
Gallic acid is known as a potent antioxidant active compound of the edible and medicinal plant Peltiphyllum peltatum. The main objective of this study was to evaluate the neuroprotective effects of gallic acid against sodium fluoride induced oxidative stress in rat brain. Gallic acid (10 and 20 mg/kg) and vitamin C
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Ameliorative effects of oleanolic acid on fluoride induced metabolic and oxidative dysfunctions in rat brain: experimental and biochemical studies
Beneficial effects of oleanolic acid on fluoride-induced oxidative stress and certain metabolic dysfunctions were studied in four regions of rat brain. Male Wistar rats were treated with sodium fluoride at a dose of 20 mg/kg b.w./day (orally) for 30 days . Results indicate marked reduction in acidic, basic and neutral
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Neuroprotective effect of ascorbic acid and ginkgo biloba against fluoride caused neurotoxicity
Excessive consumption of fluoride through drinking water or other sources lead to skeletal and dental fluorosis. According to the world health organization 23 nations are facing the problem of fluorosis. In the recent past researchers describe the non-skeletal fluorosis where soft tissues and major organs are the victims of fluoride
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Oxidative stress might be a mechanism connected with the decreased alpha 7 nicotinic receptor influenced by high-concentration of fluoride in SH-SY5Y neuroblastoma cells
The possible mechanism concerning decreased alpha 7 nicotinic acetylcholine receptor (nAChR) influenced by fluorosis was investigated. SH-SY5Y cells were exposed to fluoride within the range of 0.05-5 mM [corrected] or ferrous iron (1-100 mM) [corrected] a free radical inducer. The levels of alpha 7 nAChR expression, lipid peroxidation and protein
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Pre and post natal exposure of fluoride induced oxidative macromolecular alterations in developing central nervous system of rat and amelioration by antioxidants.
The effect of fluoride exposure during gestation and post gestation periods were studied to check the status of oxidant, antioxidant and macromolecular changes in CNS and ameliorative role of antioxidants. The pregnant Wistar albino rats were exposed to 50 and 150 ppm fluoride in drinking water and the pups born
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Fluoride & Oxidative Stress
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Nutrient Deficiencies Enhance Fluoride Toxicity
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Fluoride: Developmental Neurotoxicity.
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Fluoride content in tea and its relationship with tea quality.
J Agric Food Chem. 2004 Jul 14;52(14):4472-6. Fluoride content in tea and its relationship with tea quality. Lu Y, Guo WF, Yang XQ. Department of Tea Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310027, People's Republic of China. Abstract: The tea plant is known as a fluorine accumulator. Fluoride (F) content in fresh leaves collected
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Fluoride Affects Learning & Memory in Animals
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