Abstract
Two independent experiences with animals in captivity revealed a dramatic onset of severe debilitating symptoms when the nonfluoridated water supplies were changed to municipal water fluoridated with fluorosilicic acid, H2SiF6. The first group of animals, chinchillas in a small fur farm operation, quickly more than doubled their water consumption with the change to silicofluoridated water and gradually began to have inferior fur quality, stillbirths, and premature mortality. In the second group of animals, when a similar change in the water occurred, caimans and alligators in a noncommercial private animal collection exhibited swelling and ulceration of eye membranes and later bloated bellies, liver silicosis, spinal deformity, tumors, and shortened life spans. The health of the rat colony in this collection rapidly deteriorated and numerous tumors developed. When hatchling caimans were raised in distilled water, they remained healthy until, because of their size, they were transferred to the silicofluoridated water, after which the above symptoms began to appear. Similarly, when the rats were changed to distilled water, tumor formation ceased, and they became healthy with greatly extended life spans.
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Fluoride in Drinking Water: A Scientific Review of EPA’s Standards.
Excerpts: Summary Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might cause any adverse effects on human health. These standards include the maximum contaminant level goal (MCLG), the maximum contaminant level (MCL), and the secondary
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Absence of DNA damage in multiple organs (blood, liver, kidney, thyroid gland and urinary bladder) after acute fluoride exposure in rats
Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there has been some speculation that excess fluoride could cause an impact on genome integrity. In the current study, the potential DNA damage associated with exposure to fluoride was assessed in cells of blood, liver, kidney, thyroid
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Multigenerational evaluation of sodium fluoride in rats
Since the mid 1940s, fluoride has been added to tap water in American communities in an effort to reduce the incidence of dental caries in the population. When the levels of fluoride in drinking water were tested and set, water was the only measurable source of fluoride for most communities.
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Mutual interactions among ingredients of betel quid in inducing genotoxicity on Chinese hamster ovary cells
The purpose of this study is to explore the mutual interactions among the chemical ingredients of betel quid including arecoline, sodium fluoride, catechin and glycyrrhizin in producing genotoxicity on Chinese hamster ovary (CHO) cells using the micronucleus method. Our results show that arecoline at a rather low concentration of 0.2-2
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Fluoride intoxication and possible changes in mitochondrial membrane microviscosity and organ histology in rats
Fluoride exposure to rats can alter system physiology and biochemistry and results in abnormal organ function. Mitochondria, the power house of the cell can be act as a marker to identify fluoride mediated oxidative damage through changes of mitochondrial micro viscosity. Male albino rats were fed with 5 ppm, 10
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Fluorine recovery in the fertilizer industry - a review.
The fluorine compounds liberated during the acidulation of phosphate rock in the manufacture of phosphoric acid and fertilizers are now rightly regarded as a menace, and the industry is now obliged to suppress emissions of fluorine-containing vapours to within very low limits in most parts of the world. As with any pollution control operation, it is highly desirable for the operator of the fluorine scrubbing operation to find a use or market for the recovered fluorine to help defray at least partially the cost of the operation.
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Fluoride's Mutagenicity: The "Oral Health Research Institute's" Studies
Although many in vitro and in vivo studies have detected mutagenic effects from fluoride exposure, the Oral Health Research Institute at Indiana University's School of Dentistry has repeatedly failed to find any such effect in multiple studies on the subject.
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Fluoride's Effect on Male Reproductive System: Animal Studies
Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.
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Fluoride/Osteosarcoma Link Is Biologically Plausible
The "biological plausiblility" of a fluoride-osteosarcoma link is widely acknowledged in the scientific literature. The biological plausibility centers around three facts: 1) Bone is the principal site of fluoride accumulation, particularly during the growth spurts of childhood; 2) Fluoride is a mutagen when present at sufficient concentrations, and 3) Fluoride can stimulate the proliferation of osteoblasts (bone-forming cells).
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Fluoride & Liver Cancers in NTP Bioassay
On October 28, 1988, Battelle Columbus Laboratories submitted its Final Report to the NTP concerning the results of the Mouse study. The principal finding of Battelle's report was that a dose-dependent increase of a rare liver cancer (hepatocholangiocarcinoma) had occurred in the fluoride-treated male and female mice.
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