Abstract
To investigate the mechanism of goiter caused by fluoride, goiter model of SD rats was produced by administering sodium fluoride in drinking water. Histological section of thyroid gland was made, and inducible nitric oxide synthase (iNOS) and vessel endothelial growth factor (VEGF) were determined by RT-PCR. Results showed that the capillary vessels in thyroid glands of the rats treated with fluoride proliferated and an obvious nodular goiter occurred in the fluoride-treated rats. Compared with the control, the contents of iNOS and VEGF in the thyroid glands of the rats with fluorosis was increased significantly (P0.05). It was concluded from the results that the mechanism of goiter caused by fluoride was that fluoride induced the over-expressions of iNOS and VEGF mRNAs in thyroid gland, which caused hyperplasia of capillary vessels.
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Long-term effects of various iodine and fluorine doses on the thyroid and fluorosis in mice
OBJECTIVE: To elucidate the participation of the independent and combined long term effect of various concentrations of iodine and fluorine on the pathogenesis of goiter and fluorosis in mice. METHODS: Nine drinking water supplies with different iodine and fluorine content were prepared by combination of potassium iodate and sodium fluoride solutions in bidistilled
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[Effects of fluoride on thyroid structure in chicks].
Objective: To investigate the effects of fluoride on thyroid structure in chicks. Methods: 250 one day chicks were randomly divided into 5 groups, 50 for each. Group I was the control, and other four groups, group II, III, IV, V were fed the diets containing 500, 1,000, 1,500, 2,000 mg/kg of
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Possible protective effect of curcumin on the thyroid gland changes induced by sodium fluoride in albino rats: light and electron microscopic study.
OBJECTIVES Thyroid gland regulates the body's metabolic rate and plays an exquisitely important role in the human health. Fluoride exposure can affect thyroid function. Curcumin is a potent antioxidant that works through several mechanisms. The aim of the present study was to demonstrate the hormonal, histological, and ultrastructural changes occurred in
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[A preliminary approach to the relationship of both endemic goiter and fluorosis in the valley of Manasi River, Xin-Jiang to environmental geochemistry].
According to the geographical features of the inland basins and the motion law by which a variety of chemical elements move along the rivers and deposit in the bottom of the basins in Xinjiang,the author made a series of investigations to find out the effects of the factors of environmental
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Absence of DNA damage in multiple organs (blood, liver, kidney, thyroid gland and urinary bladder) after acute fluoride exposure in rats
Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there has been some speculation that excess fluoride could cause an impact on genome integrity. In the current study, the potential DNA damage associated with exposure to fluoride was assessed in cells of blood, liver, kidney, thyroid
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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Fluoride & Goiter
Goitre (aka goiter) is an enlargement of the thyroid gland that in some cases can produce visible swelling in the neck. The main cause of goitre is iodine deficiency. Goitre can also be caused by other things, including hypothyroidism and substances that cause goitre (goitrogens). Since as far back as the
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Fluoride, Water Hardness, and Endemic Goitre
Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.
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Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
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Mikhailets (1996): Functional state of thyroid under extended exposure to fluorides
Abnormalities in the thyroid function characterized by a decreased iodine absorption function of the thyroid, a low level T3 syndrome, and a slight increase of the TSH level are observed in cases of chronic fluorine intoxication in the industrial workers.
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