Abstract
Objective To observe the effects of fluoride on thyroid morphology,thyroid peroxidase and serum thyroid hormones.
Methods One – month ablactating SD rats were randomly divided into three groups:the control group, low-fluoride group, middle-fluoride group, high-fluoride group, fed with water containing different fluoride concentration by adding NaF respectively. Rats were sacrificed after being fed for six months. The morphology of thyroid was observed through light microscope. The TPO activity was measured with upgrade guaiacol method. Radio-immunoassay was used to detect serum thyroid hormones.
Results The major changes included increased follicles with colloid accumulation in high fluoride groups. With the dose of fluoride increasing, TPO activity significantly decreased as compared with the control group (P0.05). FT4 levels of the high-fluoride group were significantly lower compared with the control group (P0.05).
Conclusions Chronic fluoride excess leads to definite histological changes in rat thyroid, inhibiting TPO activity so that level of thyroid hormone is decreased, which shows that fluoride can cause goiter, and cause abnormal changes of thyroid metabolism function.
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Fluoride caused thyroid endocrine disruption in male zebrafish (Danio rerio)
Highlights Fluoride inhibited the growth of male zebrafish. Fluoride injured the histological structure of thyroid in male zebrafish. Fluoride changed T3 and T4 levels, and genes transcriptions involved in HPT axis. Excessive fluoride in natural water ecosystem has the potential to detrimentally affect thyroid endocrine system, but little is known
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Effects of sub-acute fluoride exposure on discrete regions of rat brain associated with thyroid dysfunction: a comparative study
Objectives: In this present in vivo study, it is intended to examine the effects of fluoride on metabolic functions of four discrete regions of rat brain associated with thyroidal insufficiency. Background: Fluoride contamination in drinking water is a major health issue. Adverse health effects of fluoride include dental and muscle fluorosis,
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Is water fluoridation a hidden cause of obesity? Histological study on thyroid follicular cells of albino rats
Introduction: Fluoride in drinking water is known to exert both beneficial and detrimental effects on health. When consumed in excess, it is known to cause adverse effects including dental fluorosis, hip fracture, bone cancer, lower intelligence, and kidney toxicity plus goiter. Aim: This study was carried out to determine the histological
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Ameliorative effect of resveratrol against fluoride-induced alteration of thyroid function in male wistar rats
Resveratrol (3,4,5-trihydroxystilbene), a polyphenol and well-known natural antioxidant has been evaluated for its protective effect against fluoride-induced metabolic dysfunctions in rat thyroid gland. Fluoride, the most abundant anions present in groundwater throughout the world, creates a major problem in safe drinking water and causes metabolic, structural, and functional injuries in
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Possible protective effect of curcumin on the thyroid gland changes induced by sodium fluoride in albino rats: light and electron microscopic study.
OBJECTIVES Thyroid gland regulates the body's metabolic rate and plays an exquisitely important role in the human health. Fluoride exposure can affect thyroid function. Curcumin is a potent antioxidant that works through several mechanisms. The aim of the present study was to demonstrate the hormonal, histological, and ultrastructural changes occurred in
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?
When people with a compensated fluoride-induced hypothyroidism move to a low-fluoride area, the fluoride-induced inhibition of the production of thyroid hormones ceases. In Scandinavia, the dietary intake of iodine is usually quite high due to iodized table salt and easy access to marine fish. Under these conditions, the elevated capacity for production of thyroid hormones may result in hyperthyroidism.
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Mikhailets (1996): Functional state of thyroid under extended exposure to fluorides
Abnormalities in the thyroid function characterized by a decreased iodine absorption function of the thyroid, a low level T3 syndrome, and a slight increase of the TSH level are observed in cases of chronic fluorine intoxication in the industrial workers.
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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Fluoride, Water Hardness, and Endemic Goitre
Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.
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