Abstract
Using the Wechsler Preschool and Primary Scale of Intelligence, we conducted a study to determine the intellectual ability of 147 four- to seven-year-old preschool children in a high fluoride zone [of a rural area of Shehezi in Xinjiang Province, China] and 83 similarly-aged children from a low fluoride zone in the same region. The results show that a high fluoride intake has a clear influence on the IQ of preschool children, manifesting itself primarily as damage to performance intelligence. The study also indicates that the proportion of preschool children living in the high fluoride area that have retarded head development (based on measurement of the circumference) is significantly greater than in the low fluoride control group, and that children with this developmental deficiency demonstrate a lower IQ than children with normal head development.
Translated by Julian Brooke for Fluoride Action Network and published with the permission of the Endemic Diseases Bulletin (China) 1996;11(1):60-2 and published in the journal Fluoride.
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Investigation on children’s growth and development under long-term fluoride exposure
Objective To study the influence on children’s growth by long-term high fluoride exposure. Methods Case group was selected in high fluoride areas and control group was selected in non-high fluoride areas. The difference of children’s growth levels were analyzed between 2 groups. Results The IQ of case group was significantly lower than that of control
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Studies of relationships between the polymorphism of COMT gene and plasma proteomic profiling and children’s intelligence in high fluoride areas
Part I – Effect of high F drinking water on children’s IQ Objective: To investigate the relationships among the children’s serum F, urine F, thyroid hormone levels and children’s IQ in the high fluoride areas. Methods: We collected the samples of the drinking water, urine and blood and measured the F concentrations,
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Effects of high iodine and high fluorine on children’s intelligence and thyroid function.
Objective: Try to find out the effects of high iodine and high fluorine on children’s intelligence and thyroid function. Methods: We selected in Qingyun County the Lidian Primary School, where the iodine and fluorine in the water are relatively high in concentration as the investigative point and Dading Primary School where the iodine and
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Study of cognitive function impairment caused by chronic fluorosis.
Objective: To investigate whether an impairment in cognitive function exists in patients diagnosed with fluoride poisoning as well as its biological basis. Methods: Individuals suffering from fluoride poisoning from a high fluorine region were selected for the study group, while healthy individuals from a nonendemic region were selected as the control group. Using
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Low-moderate fluoride exposure and intelligence among Chinese school-aged children: Role of circulating mtDNA content.
Highlights First epidemiologic study links mtDNA content with fluoride-caused lower IQ scores. MtDNA content was positively correlated to odds of having excellent intelligence. MtDNA content mediated relations of fluoride to reduced odds of excellent intelligence in girls. Mitochondrial DNA (mtDNA) content alterations are potential mediators of neuronal disorders. However, what
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