Abstract
Goal: To investigate the effects of endemic fluoride poisoning caused by coal burning on the physical development and intellectual ability of children.
Method: Using random sampling from the relevant population, 176 fluorosis sufferers aged 7–12 (the subjects) were drawn from a heavily fluoride poisoned area of Zhijin County, with 50 children without dental fluorosis (the control) selected from a less severely poisoned area. The children were subjected to tests to determine levels of urinary fluoride, physical development, and intellectual ability, followed by analysis of the various measurements.
Results: Compared to the control group, the fluorosis group showed retarded physical development, and the levels of urinary fluoride and intellectual ability were both lower than the control (P < 0.05 for both).
Conclusion: high fluoride burden has a definite effect on the intellectual and physical development of children.
Translated by Julian Brooke for Fluoride Action Network and published with the permission of the Journal of Applied Clinical Pediatrics 2005;20(9):897-9 in the journal Fluoride.
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A study of the IQ levels of four- to seven-year-old children in high fluoride areas.
Using the Wechsler Preschool and Primary Scale of Intelligence, we conducted a study to determine the intellectual ability of 147 four- to seven-year-old preschool children in a high fluoride zone [of a rural area of Shehezi in Xinjiang Province, China] and 83 similarly-aged children from a low fluoride zone in
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Association of lifetime exposure to fluoride and cognitive functions in Chinese children: A pilot study
Highlights Elevated fluoride concentrations in drinking water may be neurotoxic. We carried out a pilot study of 51 first-grade children with stable lifetime fluoride exposures. Moderate and severe fluorosis was associated with deficits in digit span total and backward scores. The dose-dependence underlying the association needs to be characterized in
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Low-moderate fluoride exposure and intelligence among Chinese school-aged children: Role of circulating mtDNA content.
Highlights First epidemiologic study links mtDNA content with fluoride-caused lower IQ scores. MtDNA content was positively correlated to odds of having excellent intelligence. MtDNA content mediated relations of fluoride to reduced odds of excellent intelligence in girls. Mitochondrial DNA (mtDNA) content alterations are potential mediators of neuronal disorders. However, what
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WITHDRAWN: Co-exposure effects of arsenic and fluoride on intelligence and oxidative stress in school-aged children: a cohort study.
This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. as of November 6, 2020 Highlights Pioneer biomonitoring study on rural children to address As and F- co-exposure. High dental Fluorosis found in relation to urinary As and F- levels in
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Reviews of developmental fluoride neurotoxicity by Grandjean and Guth et al.
An updated review by Philippe Grandjean, published in Environmental Health on December 19, 2019, of developmental fluoride neurotoxicity concluded that recent epidemiological results support the notion that elevated fluoride intake during early development can result in IQ deficits that may be considerable. He noted that the recognition of neurotoxic risks
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