Abstract
By means of an activity chamber and a Y-maze, spontaneous and conditioned-response behaviors, respectively, of adult Wistar albino rats were determined after administration of sodium fluoride (150 mg/L) and/or lead acetate (300 mg/L) in their drinking water for 30 days. The dental status and the expression of Nissl body in the brain of the rats were also tested. Results showed that fluoride (F) and/or lead (Pb) altered the frequency and duration of spontaneous activities and adversely affect conditioned-response behaviors. In addition, the expressions of Nissl body were significantly decreased in the treatment groups compared with the control group, whereas no changes were observed in the dental status among different groups. These findings indicate that F and/or Pb can influence spontaneous behaviors and lower the learning ability of rats before the appearance of dental lesions.
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Water treatment with silicofluorides and lead toxicity
Toxic metals like lead, manganese, copper and cadmium damage neurons and deregulate neurotransmitters like serotonin and dopamine (which are essential to normal impulse control and learning). Earlier studies show that - controlling for socio-economic and demographic factors - environmental pollution with lead is a highly significant risk factor in predicting
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Use of the Rey-Osterrieth Complex Figure Test for neurotoxicity evaluation of mixtures in children.
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Proteomic analysis of hippocampus in offspring male mice exposed to fluoride and lead
Fluoride and lead are two common pollutants in the environment. Previous investigations have found that high fluoride exposure can increase the lead burden. In this experiment, in order to study on the molecular mechanisms of central neural system injury induced by the above two elements, differently expressed protein spots in
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Components of Drinking Water and Risk of Cognitive Impairment in the Elderly.
The relation between aluminum, fluorine, calcium, and pH in drinking water and the risk for cognitive impairment was studied using data collected in 1988-1989 in a population-based survey of 3,777 French men and women aged 65 years and older (the Paquid study). Cognitive impairment was defined as a score lower
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Effects of chronic fluorosis on the brain.
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