Abstract

By means of an activity chamber and a Y-maze, spontaneous and conditioned-response behaviors, respectively, of adult Wistar albino rats were determined after administration of sodium fluoride (150 mg/L) and/or lead acetate (300 mg/L) in their drinking water for 30 days. The dental status and the expression of Nissl body in the brain of the rats were also tested. Results showed that fluoride (F) and/or lead (Pb) altered the frequency and duration of spontaneous activities and adversely affect conditioned-response behaviors. In addition, the expressions of Nissl body were significantly decreased in the treatment groups compared with the control group, whereas no changes were observed in the dental status among different groups. These findings indicate that F and/or Pb can influence spontaneous behaviors and lower the learning ability of rats before the appearance of dental lesions.

Excerpt:

 

Print PDF

• Related Studies :

  • Water treatment with silicofluorides and lead toxicity

    Toxic metals like lead, manganese, copper and cadmium damage neurons and deregulate neurotransmitters like serotonin and dopamine (which are essential to normal impulse control and learning). Earlier studies show that - controlling for socio-economic and demographic factors - environmental pollution with lead is a highly significant risk factor in predicting

  • Components of Drinking Water and Risk of Cognitive Impairment in the Elderly.

    The relation between aluminum, fluorine, calcium, and pH in drinking water and the risk for cognitive impairment was studied using data collected in 1988-1989 in a population-based survey of 3,777 French men and women aged 65 years and older (the Paquid study). Cognitive impairment was defined as a score lower

  • Blood lead of children in Wamiao-Xinhuai intelligence study (Letter).

    As an additional part of our investigation of an association between fluoride in drinking water and children’s intelligence in two villages of Sihong County, Jiangsu Province, China, we have now determined blood lead levels of children in that study. Blood samples (80 ?L) were collected on June 18 and 19, 2003

  • Proteomic analysis of hippocampus in offspring male mice exposed to fluoride and lead

    Fluoride and lead are two common pollutants in the environment. Previous investigations have found that high fluoride exposure can increase the lead burden. In this experiment, in order to study on the molecular mechanisms of central neural system injury induced by the above two elements, differently expressed protein spots in

  • Decreased learning ability and low hippocampus glutamate in offspring rats exposed to fluoride and lead.

    Fluoride (F) and lead (Pb) are two common environmental pollutants which are linked to the lowered intelligence, especially for children. Glutamate, a major excitatory neurotransmitter in the central nervous system, plays an important role in the process of learning and memory. However, the impact of F and Pb alone or

• Related FAN Content :

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.

  • Fluoride & IQ: 74 Studies

    • As of May 2022, a total of 83 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 74 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure to