Abstract
A study was conducted of behavioral differences in Wistar rat pups born of dams drinking water containing 1.0, 5.0, and 25 mg F/L from the day of conception. A control group drank tap water containing 0.6 mg F/L. Among 18 litters in the 25 mg/L group, four of the dams failed to produce enough milk for their pups, causing them to starve. Although no differences or abnormalities in physical development were observed, differences in motor coordination, auditory reaction, pain sensitivity, and other cognitive responses, some statistically significant, varying with time and F exposure, were noted, especially among the pups in the 25 mg/L group. Brain slices in the 25 mg/L group also showed a significantly lower average cerebral cortex thickness than in the control group (10.97 µm vs. 11.70 µm)
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Determination of the contents of amino-acid and monoamine neurotransmitters in fetal brains from a fluorosis-endemic area.
The contents of five types of amino-acid neurotransmitters and three types of monoamine neurotransmitters in the brains of fetuses aborted through induced labor in a chronic fluorosis-endemic area were determined. Findings revealed that the content of the excitatory amino acid, aspartic acid, was significantly lower than in the fetuses from
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Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada.
Key Points Question Is maternal fluoride exposure during pregnancy associated with childhood IQ in a Canadian cohort receiving optimally fluoridated water? Findings In this prospective birth cohort study, fluoride exposure during pregnancy was associated with lower IQ scores in children aged 3 to 4 years. Meaning Fluoride exposure during pregnancy may be associated
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[Effects of sodium fluoride on the activity of Ca2+Mg(2+)-ATPase in synaptic membrane in rat brain].
Effects of sodium fluoride on Ca2+Mg(2+)-ATPase activity of synaptic membrane in rat brain were studied with in vitro or in vivo methods. Concentrations of sodium fluoride of 0.3, 1.6, 8.0, 20.0 and 40.0 mmol/L can significantly inhibit the activity of the enzyme with proportions of 6.6%, 18.0%, 41.0%, 55.5% and
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Effects of fluorine on the human fetus.
In an endemic fluorosis area, 16 fetuses that were delivered during their sixth to eighth month of gestation by means of artificial abortion were collected and studied. The results [compared to 10 control fetuses from a non-endemic area] show that fluorine levels in tissues are obviously high, especially in brain, calvarium, and femur. The activity of alkaline
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The effect of fluorine on the developing human brain.
Fifteen fetuses from an endemic fluorosis area that were aborted therapeutically at the 5th–8th month of gestation were compared with 16 aborted fetuses from a non-endemic area. Stereological study of the brains showed that the numerical density of the neuron volume and the undifferentiated neuroblasts as well as the nucleus-cytoplasm ratio of the neurons were
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride & IQ: 76 Studies
• As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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