Fluoride retention is high during fluoride supplementation and increases with increasing fluoride intake. When large amounts of fluoride were given for several months the retention of fluoride was about the same as in the initial phase of fluoride supplementation, whether the supplemental dose of fluoride was 10, 20, or 45 mg per day. The rapid return of the fluoride balance to control values after the high fluoride intake was discontinued indicates that there is not only a tendency for continued retention of fluoride during the high fluoride intake but also after large amounts of fluoride have already been retained
Pharmacokinetics of 38% Silver Diamine Fluoride in Children.
Purpose: The purpose of this study was to measure serum levels and characterize the pharmacokinetics of silver and fluoride in healthy children receiving silver diamine fluoride (SDF) treatment for dental caries lesions. Methods: Children (three to 13 years old with at least one caries lesion) were recruited
Fluoride pharmacokinetics in infancy
Fluoride pharmacokinetic data are presented for infants given a fluoride supplement. Seventeen infants participated in a total of 20 studies. On one day, 0.013 mmol (0.25 mg) fluoride was given as a supplement (fluoride supplement study), and on another day a placebo was given (control study). Samples of plasma and
The tissue distribution of fluoride in a fatal case of self-poisoning.
The purpose of this paper is to report a case of fluoride poisoning along with a discussion of poisoning characteristics, analytical procedures, and a review of previous reports of fatal intoxications with analytical data. A case of suicidal ingestion of 40 mL of a rust removal agent containing hydrofluoric acid
Correlation of fluoride in drinking water with urine, blood plasma, and serum fluoride levels of people consuming high and low fluoride drinking water in Pakistan
A case-controlled study has compared urinary, blood plasma, and serum fluoride (F) levels of people living in endemic areas of the Thar Desert, Sindh, Pakistan, consuming groundwater with F concentrations as high as 4.00–10.00 mg/L with those consuming groundwater with low F levels of 0.30 mg/L. A total of 121
Fluoride content in human iliac bone: results in controls, patients with fluorosis, and osteoporotic patients treated with fluoride
The major part of fluoride ingested is fixed on calcified tissues, mainly in bone tissue, and then is progressively but slowly recycled during bone remodeling. Thus, the measurement of bone fluoride content allows the determination of the extent of bone fluoride retention, and this parameter constitutes a useful complement to
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