Abstract
A case-controlled study has compared urinary, blood plasma, and serum fluoride (F) levels of people living in endemic areas of the Thar Desert, Sindh, Pakistan, consuming groundwater with F concentrations as high as 4.00–10.00 mg/L with those consuming groundwater with low F levels of 0.30 mg/L. A total of 121 individuals from Samme Jo Tar Village of the Chachro Sub-District, Tharparker, and 121 controls from Gadap Town, Karachi, Pakistan, were selected for this study. Results indicated highly significant differences were present between the mean urinary F (12.90 versus 2.30 mg/L, p<0.001), plasma F (0.61 versus 0.25 mg/L, p<0.001) and serum F levels (0.75 versus 0. 29 mg/L, p<0.001) of cases and controls. There was a strong positive correlation between plasma and serum F levels (r = 0.884), while moderate correlations were found between urine plus plasma and between urine plus serum (r = 0.576 an d 0.621) F levels of cases, respectively.
Excerpt:
… The accompanying fluorosis problem can be observed at various intensity levels in the study area ranging from dental fluorosis to debilitating skeletal fluorosis, along with nonskeletal manifestations and premature aging…
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FRZB1 rs2242070 polymorphisms is associated with brick tea type skeletal fluorosis in Kazakhs, but not in Tibetans, China.
Skeletal fluorosis is a metabolic bone and joint disease caused by excessive accumulation of fluoride in the bones. Compared with Kazakhs, Tibetans are more likely to develop moderate and severe brick tea type skeletal fluorosis, although they have similar fluoride exposure. Single nucleotide polymorphisms (SNPs) in frizzled-related protein (FRZB) have
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[Study on determinationing the bone mineral content as diagnostic value for occupational fluorosis].
The results of determination of the bone density of 194 workers exposed to fluorine by SPA-III type osteodensimeter were compared with people unexposed to fluorine, and with the results of diagnosing the fluorosis by X-ray. (1) The abnormal bone cortex thickness and density rate in the people exposed to fluorine
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A national cross-sectional study on effects of fluoride-safe water supply on the prevalence of fluorosis in China
OBJECTIVE: To assess the effects of provided fluoride-safe drinking-water for the prevention and control of endemic fluorosis in China. DESIGN: A national cross-sectional study in China. SETTING: In 1985, randomly selected villages in 27 provinces (or cities and municipalities) in 5 geographic areas all over China. PARTICIPANTS: Involved 81 786 children aged from
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Prevention of bony fluorosis in aluminum smelter workers. A 15-year retrospective study of fluoride excretion and bony radiopacity among aluminum smelter workers -- Pt. 4
1. Fifty six aluminum smelter workers with 10 to 43 years' occupational exposure, and who had been previously studied medically, were re-x-rayed. Average urinary fluoride concentrations since 1960 were estimated to range from 2.78 mg/liter preshift and 7.71 mg/liter postshift. 2. Roentgenographic studies in 1960-66 and 1974 failed to reveal
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[Comparison of the therapeutic effect on skeletal fluorosis and impact on urine fluoride value among fire needle therapy, electroacupuncture and calcium carbonate D3].
OBJECTIVE: To observe the impacts on skeletal fluorosis pain, joint motor dysfunction and urine fluoride excretion in the treatment with fire needle therapy, electroacupuncture and calcium carbonate D3. METHODS: The randomized controlled trial was adopted. Ninety-five patients were randomized into a fire needle group (31 cases), an electroacupuncture group (33 cases) and a
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Mayo Clinic: Fluoridation & Bone Disease in Renal Patients
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