Abstract
The occupational fluorosis risk factors were estimated in a three- stage study among the workers of aluminum and cryolite plants using dennatoglyphics as a genetic marker. This study helped: 1) to establish the existence of genetic predisposition to fluorosis and develop criteria for estimating it, and 2) to prove that predisposition to fluorosis was associated with the same dermatoglyphic features in the workers of both industrial groups. Multifactorial analysis of the set of 15 genetic and non-genetic factors was performed with the help of pattern recognition methods, and demonstrated reliable (90-100%) discrimination between two groups of workers: those who had developed fluorosis and those who had not. Each of the 15 risk factors under study was examined for the degree and the direction of influence. A PC software program was developed in the course of the study, making possible the estimation of individual predisposition to the disease. The method was used to investigate 397 disease- free workers in the electrolysis shop of an aluminum plant. Predisposition to fluorosis was discovered in 22 of them (5.5%)
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Fluoride enhances the effect of aluminium chloride on interconnections between aggregates of hippocampal neurons
The role of fluoride in aluminium neurotoxicity was studied using an in vitro system of cultured hippocampal neurons from foetal rats. Sodium fluoride (50 microM) and aluminium chloride (12.5 microM) were administered alone or in a specific combination (50 + 12.5 microM) in a 14-day culture in a chemically defined
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Dementia, aluminum, and fluoride.
Letter to the Editor No abstract available. *See https://doi.org/10.1016/0140-6736(91)92411-T
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When less is more: a comparison of models to predict fluoride accumulation in free-ranging kangaroos.
Highlights Exposure models can predict toxic effects of fluoride consumption in wildlife. Exposure models that vary in intensity of field data collection warrant comparison. Simple spatial metrics can predict fluoride accumulation in a free-ranging mammal. Complex exposure models may not perform better than simple spatial metrics. Vegetation contaminated by industrial fluoride
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Components of Drinking Water and Risk of Cognitive Impairment in the Elderly.
The relation between aluminum, fluorine, calcium, and pH in drinking water and the risk for cognitive impairment was studied using data collected in 1988-1989 in a population-based survey of 3,777 French men and women aged 65 years and older (the Paquid study). Cognitive impairment was defined as a score lower
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Thyroid function tests in aluminum potroom workers exposed to fluoride emissions.
Following a previous study on parathyroid hormone determinations in 200 aluminum potroom workers, we conducted a cross-sectional survey of 116 (58%) of these workers for their levels of serum triiodothyronine (T3), tetraiodothyronine (T4), thyroid stimulating hormone (TSH), urinary creatinine, and preshift urinary fluoride (F). The mean serum TSH measured by
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Factors which increase the risk for skeletal fluorosis
The risk for developing skeletal fluorosis, and the course the disease will take, is not solely dependent on the dose of fluoride ingested. Indeed, people exposed to similar doses of fluoride may experience markedly different effects. While the wide range in individual response to fluoride is not yet fully understood, the following are some of the factors that are believed to play a role.
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Dental Fluorosis & Enamel Hypoplasia in Children with Kidney Disease
Children with kidney disease are known to have high levels of fluoride in their blood and to be at risk for disfiguring tooth defects. Research suggests that high levels of fluoride in blood, which can cause the tooth defect known as dental fluorosis, can contribute to the defects that occur
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Fluoride Exposure Aggravates the Impact of Iodine Deficiency
A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and
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Fluoridation, Dialysis & Osteomalacia
In the 1960s and 1970s, doctors discovered that patients receiving kidney dialysis were accumulating very high levels of fluoride in their bones and blood, and that this exposure was associated with severe forms of osteomalacia, a bone-softening disease that leads to weak bones and often excruciating bone pain. Based on
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Skeletal Fluorosis & Individual Variability
One of the common fallacies in the research on skeletal fluorosis is the notion that there is a uniform level of fluoride that is safe for everyone in the population. These "safety thresholds" have been expressed in terms of (a) bone fluoride content, (b) daily dose, (c) water fluoride level, (d) urinary fluoride level, and (e) blood fluoride level. The central fallacy with each of these alleged safety thresholds, however, is that they ignore the wide range of individual susceptibility in how people respond to toxic substances, including fluoride.
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