Eight 14-week-old male Wistar FL strain rats were administered sodium fluoride in a single intraperitoneal dose (35 mg NaF/kg of bw). After 90 min the rats were fatally anesthetized with ether, and blood samples were taken. Compared to ten control rats, fluoride-treated rats developed hyperglycemia accompanied by a statistically significant increase in the concentration of fluoride, creatinine, and urea and a decrease in the level of protein and calcium in the blood serum. The results indicate disturbances in the filtrating function of kidneys in rats.
Diagnosis of fluorosis and recovery through easy to practise interventions.
The objectives of the present study were to highlight (i) how to diagnose fluorosis, due to fluoride ion (F) toxicity, in out-patient departments, by retrieving the history and through tests and (ii) the interventions available for recovery. In patients suspected of fluorosis, the F levels were investigated in samples of
Serum inorganic fluoride: changes related to previous fluoride intake, renal function and bone resorption
1. Inorganic fluoride concentrations were determined in serum and urine specimens of 24 subjects receiving a standardized low fluoride intake. Serum fluoride was directly correlated with previous intake and appeared to reflect bone fluoride stores. 2. A positive correlation between creatinine and fluoride clearance was found. However, striking reductions in
Serum ionic fluoride concentrations are related to renal function and menopause status but not to age in a Japanese general population
BACKGROUND: There have been no studies in which fasting serum ionic fluoride (SIF) concentrations in a general population were investigated despite the fact that SIF has various activities in humans. METHODS: A total of 332 healthy subjects (167 men and 165 women aged 40 to 69years) were selected from residents of
Sodium fluoride induces nephrotoxicity via oxidative stress-regulated mitochondrial SIRT3 signaling pathway.
Accumulation of mitochondrial reactive oxygen species (mROS) has been implicated in the pathogenesis of fluorosis. As the main mitochondrial deacetylase, SIRT3 is closely associated with oxidative stress. To investigate the role of SIRT3 in response to sodium fluoride (NaF)-induced nephrotoxicity. Our results showed that NaF treatment impaired mitochondrial ultrastructure, decreased
Ionic plasma fluoride concentrations related to some diseases in patients from a fluoridated community
Little data is available concerning the relationship between variations in ionic plasma fluoride (IPF) concentrations and some diseases, and that which exists is inconclusive. The effect of renal insufficiency is known best, but the relationship between IPF levels and some oedematous diseases and diabetes has hardly been studied at all
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