Abstract
Eight 14-week-old male Wistar FL strain rats were administered sodium fluoride in a single intraperitoneal dose (35 mg NaF/kg of bw). After 90 min the rats were fatally anesthetized with ether, and blood samples were taken. Compared to ten control rats, fluoride-treated rats developed hyperglycemia accompanied by a statistically significant increase in the concentration of fluoride, creatinine, and urea and a decrease in the level of protein and calcium in the blood serum. The results indicate disturbances in the filtrating function of kidneys in rats.
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Long-term follow up of ionic plasma fluoride level in patients receiving hemodialysis treatment
The elimination half-life of fluoride is significantly increased in patients with chronic renal failure. This led us to conduct a study of variations of its plasma levels in 35 patients receiving dialysis treatment. In this population, there is a gaussian distribution of the values before and after the hemodialysis session,
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Reversible skeletal disease and high fluoride serum levels in hematologic patients receiving voriconazole.
We here investigate the occurrence of fluoride intake-associated alterations in patients with hematologic disease on triazol antifungal medication. Clinical, laboratory, and radiology data of overall 43 patients with hematologic malignancies taking voriconazole (n = 20), posaconazole (n = 8), and itraconazole (n = 4), and a hematologic patient control group
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Ionic serum fluoride concentrations and age in a low-fluoride community
Some previous studies indicate extra fluoride retention in human bones caused by severe renal insufficiency. Plasma and serum fluoride concentrations may also be elevated in a fluoridated community. The results from low-fluoride areas are less consistent. The first aim of the present study was thus to test the relation between
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Effect of Fluoride on the Expression of 8-Hydroxy-2'-Deoxyguanosine in the Blood, Kidney, Liver, and Brain of Rats.
Excessive exposure of fluoride not only leads to damage on bone, but also has an adverse effect on soft tissues. Oxidative DNA damage induced by fluoride is thought to be one of the toxic mechanisms of fluoride effect. However, the dose–response of fluoride on oxidative DNA damage is barely studied
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Serum and urine fluoride concentration: relationships to age, sex and renal function in a non-fluoridated population
Serum and urine fluoride levels were determined in 250 healthy subjects (15-90 years, 122 men and 128 women) residing in Catalonia, Spain, and in 150 patients (20-81 years, 84 men and 66 women) with chronic renal failure undergoing regular dialysis treatment, living in the same geographical area, to determine normal
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