Abstract

The effect of prolonged administration of NaF on the metabolism of (guinea pig) Purkinje cells in the cerebellar cortex was studied by histochemical methods. Experimentation showed an intensification of the metabolic activity of the mitochondria and probably of the membrane system of the endoplasmic reticulum, activation of the complex of enzymes connected with active transport through membrane structures of cells and the absence of perceptible changes in the process of protein synthesis in experimental animals as compared with controls. The intensified activity of the enymatic complexes is probably connected with the excitation of the neurons provoked by the introduction of a toxic substance.

• Related Studies :

  • Report on the intellectual ability of children living in high-fluoride water areas

    Note from Fluoride Action Network: This is a duplicate study of Lu et al. (2000). SUMMARY: Sixty children, aged 10 to 12, were randomly selected for IQ testing from an area with high fluoride (3.15 mg F/L) in the drinking water along with 58 control children of the same age from a nearby low fluoride

  • Biochemical effects of sodium fluoride and arsenic trioxide toxicity and their reversal in the brain of mice

    SUMMARY: Sodium fluoride (NaF) and arsenic trioxide (As2O3), singly or combined, at doses of 5 and 0.5 mg/kg body weight, respectively, were administered orally to mice for 30 days to investigate their biochemical effects on the brain (cerebral hemisphere). The effects of withdrawal of the treatment and ingestion of vitamin

  • Effect of concurrent chronic exposure of fluoride and aluminum on rat brain.

    The present in vivo study was designed to investigate the toxic potential of fluoride alone and in conjugation with aluminum on the rat brain. The region-specific response of both elements was studied in different regions of brain, namely the cerebrum, cerebellum, and medulla oblongata. Following fluoride exposure, oxidative stress increased

  • Chronic fluoride exposure induces neuronal apoptosis and impairs neurogenesis and synaptic plasticity: role of GSK-3ß/ß-catenin pathway.

    Highlights Fluoride dose-dependently impaired neurogenesis and synaptic function. Fluoride exposure induced hippocampal neuronal loss and apoptosis. Fluoride exposure compromised GSK-3ß/ß catenin signaling. Fluoride decreased ß-catenin downstream target genes, cyclin D1 and c-myc. Fluoride is becoming an ineluctable environmental pollutant and its longterm exposure would cause fluorosis and irreversible brain damage,

  • Human epiphyseal concrements in schizophrenia.

    The epiphysis is a gland containing firm extracellular bodies (brain sand) the number of which increases with age. Microscopy and roentgen microtomography showed that in some cases of schizophrenia the amount of brain sand decreases. In parallel, cytoplasm of pinealocytes appears to contain concrements of a new type--irregular hollow spheres

• Related FAN Content :

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.

  • Fluoride & IQ: 76 Studies

    • As of July 18, 2022, a total of 85 human studies have investigated the relationship between fluoride and human intelligence. • Of these investigations, 76 studies have reported that elevated fluoride exposure is associated with reduced IQ in humans. • The studies which reported an association of reduced IQ with exposure

  • Fluoride's Effect on Fetal Brain

    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.