Abstract
Abstract is not available
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Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats
Nine-six Wistar rats were randomly divided into four groups of 24 rats in each group (female:male = 1:1). Over a period up to 90 days, with one untreated group as controls, the other three groups were administered, respectively, high fluoride (100 mg NaF/L), high arsenic (50 mg As2O3/L), or both
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Fluoride intoxication and possible changes in mitochondrial membrane microviscosity and organ histology in rats
Fluoride exposure to rats can alter system physiology and biochemistry and results in abnormal organ function. Mitochondria, the power house of the cell can be act as a marker to identify fluoride mediated oxidative damage through changes of mitochondrial micro viscosity. Male albino rats were fed with 5 ppm, 10
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Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells.
Highlights Fluoride induced apoptosis in SH-SY5Y cells. Fluoride induced apoptosis via activating mitochondrial p53 apoptotic pathway. Fluoride inhibited SIRT1 deacetylase activity to activate p53. SIRT1 is a promising target to protect against fluoride-induced neurotoxicity. There has been a great concern about the neurotoxicity of fluoride since it can pass through the
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Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain-pituitary-gonadal axis in male rats.
Excessive exposure to fluoride is associated with male reproductive dysfunction in humans and animals. Taurine (2-aminoethane sulfonic acid) is a free intracellular ?-amino acid with antioxidant, anti-inflammatory, and neuroprotective properties. However, the effect of taurine on fluoride-induced reproductive toxicity has not been reported. The present study investigated the influence of
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Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats.
Highlights The influence of rutin on fluoride – induced neurotoxicity in rat was studied. Rutin reversed the fluoride – induced neurobehavioral deficits in rats. Rutin reversed the fluoride – induced inhibition of acetylcholinesterase activity in rat cerebrum and striatum. Rutin enhanced antioxidant status and inhibited neuro-inflammation and apoptosis in fluoride
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Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
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Fluoride & IQ: 70 Studies
As of June 2021, a total of 78 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 70 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
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