Abstract

Report on an 86-year-old man with massive skeletal fluorosis. The disease arose during chronic exposure to fluorides from renal insufficiency caused by arteriosclerosis. The importance of knowing the renal functional parameters in cases of therapeutic use of fluorides is accentuated.

• Related Studies :

  • Studies on serum fluoride and bone metabolism in patients with long term hemodialysis

    With growing experience of the long-term treatment of patients with end stage renal disease by hemodialysis, the safety of fluoridated water supply for dialysate and the effect on the bone metabolism has been discussed. In this study, concentrations of fluoride (F), calcium (Ga). aluminum (AI) and biochemical indices of bone metabolism,

  • [Histomorphometric profile of bone fluorosis induced by prolonged ingestion of Vichy Saint-Yorre water. Comparison with bone fluorine levels].

    Nine transiliac bone biopsies from 7 patients with skeletal fluorosis due to prolonged ingestion of often high quantities of Vichy Saint-Yorre water were analyzed. Four of these patients also suffered from a chronic renal failure. A histomorphometric study was possible in 8 out of the 9 biopsies. The measurement of bone fluoride

  • Bone fluoride in patients with uremia maintained by chronic hemodialysis

    Bone specimens from 42 patients with end-stage renal disease and from 9 patients without renal or bone disease have been analyzed for the content of fluoride, calcium, and phosphorus. Thirty-one patients were treated with chronic hemodialysis for periods ranging up to 56 months by employing dialysate made up with tap

  • The relationship of creatinine clearance to serum fluoride concentration and urinary fluoride excretion in man

    The effects of renal function on urinary fluoride clearance and serum inorganic fluoride concentration were studied. Laboratory determinations including (1) creatinine clearance rate (CCR), (2) serum inorganic fluoride concentration, and (3) urinary fluoride concentration, were made on 122 hospital patients. Subjects were then divided into impaired, questionable and normal creatinine

  • Fluoride aggravation of oxidative stress in patients with chronic renal failure.

    Based on evidence that fluoride ion (F) increases the production of reactive oxygen species, inhibits antioxidant enzyme activity, and enhances lipid peroxidation, a study of these effects was conducted on 52 patients with chronic renal failure (CRF), of whom 33 were under going chronic haemodialysis (HD) with the use of polysulphone membrane dialysers, while 19 with

• Related FAN Content :

  • Skeletal Fluorosis in the U.S.

    Although there has been a notable absence of systematic studies on skeletal fluorosis in the U.S., the available evidence indicates that the consumption of artificially fluoridated water is likely to cause skeletal fluorosis and other forms of bone disease in people with kidney disease and other vulnerable populations.

  • Dental Fluorosis & Enamel Hypoplasia in Children with Kidney Disease

    Children with kidney disease are known to have high levels of fluoride in their blood and to be at risk for disfiguring tooth defects. Research suggests that high levels of fluoride in blood, which can cause the tooth defect known as dental fluorosis, can contribute to the defects that occur

  • Similarities between Skeletal Fluorosis and Renal Osteodystrophy

    It is quite possible, and indeed likely, that some kidney patients diagnosed with renal osteodystrophy are either suffering from skeletal fluorosis or their condition is being complicated/exacerbated by fluoride exposure.

  • Exposure Pathways Linked to Skeletal Fluorosis

    Excessive fluoride exposure from any source -- and from all sources combined -- can cause skeletal fluorosis. Some exposure pathways , however, have been specifically identified as placing individuals at risk of skeletal fluorosis. These exposure pathways include: Fluoridated Water for Kidney Patients Excessive Tea Consumption High-Fluoride Well Water Industrial Fluoride Exposure Fluorinated Pharmaceuticals (Voriconazole

  • Fluoride & Osteomalacia

    One of fluoride's most well-defined effects on bone tissue is it's ability to increase the osteoid content of bone. Osteoid is unmineralized bone tissue. When bones have too much of it, they become soft and prone to fracture -- a condition known as osteomalacia. As shown below, fluoride has repeatedly been