Abstract
Various authors have studied the effect of fluoride ion upon mammalian cells using many different biological end-points, of:which inhibition of the function of specific cellular enzymes, survival of cell reproductive capacity, production of abnormalities of cell division and alteration in the rate of cell proliferation are a representative sample. In this review the minimum fluoride ion concentration at which biological effects are detect- able are compared for each of these end-points. The usefulness of such in vitro studies for evaluation of potential whole-animal toxicity is discussed.
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JNK and NADPH oxidase involved in fluoride-induced oxidative stress in BV-2 microglia cells.
Abstract Excessive fluoride may cause central nervous system (CNS) dysfunction, and oxidative stress is a recognized mode of action of fluoride toxicity. In CNS, activated microglial cells can release more reactive oxygen species (ROS), and NADPH oxidase (NOX) is the major enzyme for the production of extracellular superoxide in microglia. ROS
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Effect of topical application of fluoride gel NaF 2% on enzymatic and non-enzymatic antioxidant parameters of saliva
OBJECTIVE: The aim of the study was to evaluate the effect of topical fluoride gel NaF 2% application on antioxidant parameters of whole saliva from children. DESIGN: The saliva mechanically stimulated with parafilm was collected from 25 children (6-12 years) attending the Clinic of Paediatric Dentistry of Universidade Cruzeiro do
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Lipid peroxidation and antioxidant enzyme status of adult males with skeletal fluorosis in Andhra Pradesh, India.
Blood samples from 24 adult males, age 25 to 40, with endemic skeletal fluorosis, living in the Vaillapally village of the Nalgonda district, Andhra Pradesh, India, were examined and compared with samples from 15 matched controls for their antioxidant enzyme activity and lipid peroxidation. Elevated malondialdehyde (MDA) levels indicated an
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[Effect of endemic fluoride poisoning caused by coal burning on the oxidative stress in rat testis].
OBJECTIVE: To explore the effect of endemic fluoride poisoning caused by coal burning on the oxidative stress in rat testis. METHODS: Totally 40 male SD rats were equally randomized into four groups control group, low fluorosis group, middle fluorosis group, and high fluorosis group. Rats in all three fluorosis groups were
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Co-exposure to arsenic and fluoride on oxidative stress, glutathione linked enzymes, biogenic amines and DNA damage in mouse brain.
We studied the effects of combined exposure to arsenic and fluoride on (i) brain biogenic amines, oxidative stress and its correlation with glutathione and linked enzymes; (ii) alterations in the structural integrity of DNA; and (iii) brain and blood arsenic and fluoride levels. Efficacy of alpha-tocopherol in reducing these changes
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