Abstract
A case-controlled study has compared urinary, blood plasma, and serum fluoride (F) levels of people living in endemic areas of the Thar Desert, Sindh, Pakistan, consuming groundwater with F concentrations as high as 4.00–10.00 mg/L with those consuming groundwater with low F levels of 0.30 mg/L. A total of 121 individuals from Samme Jo Tar Village of the Chachro Sub-District, Tharparker, and 121 controls from Gadap Town, Karachi, Pakistan, were selected for this study. Results indicated highly significant differences were present between the mean urinary F (12.90 versus 2.30 mg/L, p<0.001), plasma F (0.61 versus 0.25 mg/L, p<0.001) and serum F levels (0.75 versus 0.29 mg/L, p<0.001) of cases and controls. There was a strong positive correlation between plasma and serum F levels (r = 0.884), while moderate correlations were found between urine plus plasma and between urine plus serum (r = 0.576 and 0.621) F levels of cases, respectively.
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Plasma and water fluoride levels and hyperuricemia among adolescents: A cross-sectional study of a nationally representative sample of the United States for 2013–2016.
Highlights Relatively low levels of fluoride exposure in US adolescents but with wide ranges. Dose-dependent increase in prevalence of hyperuricemia with increasing fluoride levels. Significant associations between plasma and water fluoride and hyperuricemia. A positive relationship between water and plasma fluoride concentrations. Potential role of chronic fluoride exposure in
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Selenium may suppress peripheral blood mononuclear cell apoptosis by modulating HSP70 and regulate levels of SIRT1 through reproductive hormone secretion and oxidant stress in women suffering fluorosis.
Excessive taking fluoride (F) causes severe damage to reproductive system through stimulation of apoptosis and oxidant stress. Selenium (Se) may promote anti-oxidant enzymes and invert cell apoptosis. The aim of this study was to investigate the effect of Se on peripheral blood mononuclear cell (PBMC) apoptosis and oxidant stress in
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Serum and urine fluoride concentration: relationships to age, sex and renal function in a non-fluoridated population
Serum and urine fluoride levels were determined in 250 healthy subjects (15-90 years, 122 men and 128 women) residing in Catalonia, Spain, and in 150 patients (20-81 years, 84 men and 66 women) with chronic renal failure undergoing regular dialysis treatment, living in the same geographical area, to determine normal
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The association of fluoride in drinking water with serum calcium, vitamin D and parathyroid hormone in pregnant women and newborn infants.
Background: Chronic exposure to fluoride in drinking water causes an increase in plasma fluoride levels that is related to a reduction in calcium transport across the renal tubule endoplasmic reticulum and plasma membrane. In the present study, it was hypothesised that varying levels of fluoride present in drinking
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Urinary and plasma fluoride levels in pregnant women from Mexico City
Highlights There is growing concern that fluoride may be a neurodevelopmental toxicant. We characterize urine and plasma fluoride levels in 872 pregnant mothers. Fluoride levels through pregnancy were relatively stable. Background: There is need to assess the developmental neurotoxicity of fluoride. Our knowledge of prenatal fluoride exposure is challenged as few
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Mayo Clinic: Fluoridation & Bone Disease in Renal Patients
The available evidence suggests that some patients wtih long-term renal failure are being affected by drinking water with as little as 2 ppm fluoride. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers and if fluoride is indeed the cause. It would seem prudent, therefore, to monitor the fluoride intake of patients with renal failure living in high fluoride areas.
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Dental Fluorosis & Enamel Hypoplasia in Children with Kidney Disease
Children with kidney disease are known to have high levels of fluoride in their blood and to be at risk for disfiguring tooth defects. Research suggests that high levels of fluoride in blood, which can cause the tooth defect known as dental fluorosis, can contribute to the defects that occur
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Kidney Patients Are at Increased Risk of Fluoride Poisoning
It is well established that individuals with kidney disease are susceptible to suffering bone damage and other ill effects from low levels of fluoride exposure. Kidney patients are at elevated risk because when kidneys are damaged they are unable to efficiently excrete fluoride from the body. As a result, kidney patients
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Unheeded Warnings: Government Health Authorities Ignore Fluoride Risk for Kidney Patients
Despite the well known fact that individuals with kidney disease are at much higher risk of fluoride toxicity than the general population, there has yet to be any attempt in the United States, or any other country that practices mass-scale water fluoridation to determine the prevalence of fluoride-related effects (e.g.,
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Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
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