Fluoride Action Network


Daily dosages of 5 and 10 mg NaF/kg bw were administered orally to male rats (15 per group) for 60 days to evaluate the effect on the testis in relation to oxidative stress. A significant decrease in body and organ weights occurred compared to controls. Alterations in the antioxidant indices in the testis were confirmed by increased lipid peroxidation (LPO) along with decrements in antioxidant parameters such as glutathione peroxidase (GPx), glutathione (GSH), total ascorbic acid (TAA), glutathione-S-transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT) levels affecting testis function as indicated by histopathological study. Supplementation of the NaF-treated rats by the antioxidant melatonin (10 mg/kg bw) revealed a significant protection to the gonadal function, thus indicating a mitigating effect by melatonin against NaF- induced testis toxicity and oxidative stress in a rat model.