Abstract
Daily dosages of 5 and 10 mg NaF/kg bw were administered orally to male rats (15 per group) for 60 days to evaluate the effect on the testis in relation to oxidative stress. A significant decrease in body and organ weights occurred compared to controls. Alterations in the antioxidant indices in the testis were confirmed by increased lipid peroxidation (LPO) along with decrements in antioxidant parameters such as glutathione peroxidase (GPx), glutathione (GSH), total ascorbic acid (TAA), glutathione-S-transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT) levels affecting testis function as indicated by histopathological study. Supplementation of the NaF-treated rats by the antioxidant melatonin (10 mg/kg bw) revealed a significant protection to the gonadal function, thus indicating a mitigating effect by melatonin against NaF- induced testis toxicity and oxidative stress in a rat model.
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Management of fluoride induced testicular disorders by calcium and vitamin-E co-administration in the albino rat
Fluoride contamination of drinking water can disrupt male gametogenesis and steroidogenesis and induce testicular oxidative stress. Treatment of rats with sodium fluoride at the dose of 20 mg/kg/day for 28 days resulted in significant diminution of testicular Delta5,3beta-hydroxysteroid dehydrogenase (HSD) and 17beta-hydroxysteroid dehydrogenase (HSD) activities and low plasma levels of
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[Study on antagonistic effects of selenite on fluoride-induced impairments of testis and epididymis in rats].
Objective: To study the mechanisms of the antagonistic action of selenite on fluoride-induced male reproductive damages, and find out the optimal level of selenite in drinking water against fluoride toxicity. Methods: Five groups of SD male rats were provided with deionized drinking water containing 0 and 150 mg/L NaF, and
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Sodium fluoride causes oxidative damage to silkworm (Bombyx mori) testis by affecting the oxidative phosphorylation pathway.
Highlights Fluoride induced reproductive damage in silkworms is closely linked to the oxidative phosphorylation pathway. The root cause of ROS formation is increased activity of mitochondrial complexes I, III, IV and V in the silkworm testis. The accumulation of ROS (H2O2 and O2-) in the testis may be the
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Antagonistic effect of calcium against fluorosis induced oxidative stress in rat testis
[Objective] To investigate the effects of fluoride on catalase (CAT) , lactate dehydrogenase (LDH) , and malonic dialdehyde (MDA) in rat testis and the potential antagonism against these effects by calcium. [Methods] Eighty healthy male SD rats were equally randomized into 10 groups: 1 control group, 6 fluorosis groups with
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Testicular toxicity in sodium fluoride treated rats: association with oxidative stress
This study examined the effect of sodium fluoride, a water pollutant important through the world, including India, on testicular steroidogenic and gametogenic activities in relation to testicular oxidative stress in rats. Sodium fluoride treatment at 20mg/kg/day for 29 days by oral gavage resulted in significant diminution in the relative wet
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Fluoride's Effect on the Male Reproductive System -- In Vitro Studies
Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.
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Fluoride's Effect on Male Reproductive System - Human Studies
Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.
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Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly
In contrast to the findings of over 60 animal studies from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study
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Fluoride content in tea and its relationship with tea quality.
J Agric Food Chem. 2004 Jul 14;52(14):4472-6. Fluoride content in tea and its relationship with tea quality. Lu Y, Guo WF, Yang XQ. Department of Tea Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310027, People's Republic of China. Abstract: The tea plant is known as a fluorine accumulator. Fluoride (F) content in fresh leaves collected
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Fluoride & Oxidative Stress
A vast body of research demonstrates that fluoride exposure increases oxidative stress. Based on this research, it is believed that fluoride-induced oxidative stress is a key mechanism underlying the various toxic effects associated with fluoride exposure. It is also well established that fluoride's toxic effects can be ameliorated by exposure
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