Abstract
As part of a 2002-2003 investigation on the effects of high fluoride drinking water on IQ scores of children, serum fluoride (F) levels in the children were subjected to further study. Among the new findings, although IQ scores of boys and girls differed in the seven IQ level categories, there were no overall gender differences (boy/girl ratio 1.220 vs. 1.214 in the high and low F villages, respectively). However, the mean IQ was significantly higher and there were fewer children with an IQ less than 80 in the two quartiles with a serum fluoride level of less than 0.05 mg F/ L. Analysis of the overall relationship between IQ scores and serum F levels indicates there may be no serum F level below which adverse effects on IQ might not be present.
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Studies of relationships between the polymorphism of COMT gene and plasma proteomic profiling and children’s intelligence in high fluoride areas
Part I – Effect of high F drinking water on children’s IQ Objective: To investigate the relationships among the children’s serum F, urine F, thyroid hormone levels and children’s IQ in the high fluoride areas. Methods: We collected the samples of the drinking water, urine and blood and measured the F concentrations,
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Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?
Background: Excessive exposure to fluoride can reduce intelligence. Methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 (MTHFD1) polymorphisms have important roles in neurodevelopment. However, the association of MTHFD1 polymorphisms with children's intelligence changes in endemic fluorosis areas has been rarely explored. Methods: A cross-sectional study was conducted in four randomly selected primary schools in
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Comparative assessment of the physical and mental development of children in endemic fluorosis area with water improvement and without water improvement.
Tests were performed to compare the IQ and physical development of 7-to-14-year-old children from endemic fluorosis areas, with and without water improvement programs, with children from a nonfluorosis area. The results showed that the average IQ of children in each age group from the fluorosis area without water improvement is lower than those
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Assessment of intelligence quotient among schoolchildren of fishermen community of Kutch, Gujarat, India
Background and aim: The aim of the study was to assess the intelligence quotient of fishermen schoolchildren of Kutch, Gujarat, India. Materials and methods: A descriptive cross-sectional study was conducted among 8 to 10 years old schoolchildren living in Kutch District, Gujarat, India, from January to February 2013. Seguin Form Board
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Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence.
Highlights Childhood fluoride exposure was inversely associated with dental health and IQ. Threshold and saturation effects for aforementioned associations existed. Moderate fluoride exposure was mainly related to excellent intelligence loss. Dental fluorosis may be useful to reflect excellent intelligence loss. BACKGROUND: Excessive fluoride exposure is associated with adverse health outcomes, but
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Fluoride & IQ: 76 Studies
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Fluoride Affects Learning & Memory in Animals
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