Fluoride is a well determined non-biodegradable and moderate pollutant, which at high levels causes serious health problems. The present study was designed to investigate the histopathalogical changes in liver and kidney of exposure to sodium fluoride in albino mice. Eighteen adult albino mice were divided into 3 groups (6 mice per each group). The first group is served as controls and received de-ionized water. The second group is treated with 5 ppm of sodium fluoride for 15 days and third group is treated with 5 ppm of sodium fluoride for 30 days. At the end of the treatment period, the animals are sacrificed by cervical dislocation and liver, kidney was dissected out. The adhesive tissue is cleared and used for assess the histopathalogical changes. The histopathalogical results in the present study indicate that exposure to sodium fluoride for 15 and 30 days caused to cytoplasmic, hepatocytes, vacuoles cellular and nucleus in liver. Moreover, exposure to sodium fluoride for 15 and 30 days results in necrosis in glomerules, Convolated tubules and bowman’s capsule lumen in kidney.