Abstract
Sodium fluoride was administered at 0, 25, 50, 100, and 150 ppm F in drinking water for 4 weeks to Institute of Cancer Research (ICR) derived glomerulonephritis (ICGN) mice. Fluoride was also administered to ICR mice at 0 and 150 ppm. Blood was sampled from the tail artery of each mouse twice a week for the determination of blood urea nitrogen (BUN) and creatinine (CRE). All ICGN mice in the 150 ppm F group and 4 of 9 in the 100 ppm F group died before the end of four weeks, but no ICR control mice died. The mean values of BUN and CRE in the serum of the 150 ppm ICGN mice were significantly higher than those in the ICGN control mice at the end of the exposure period. The mean relative liver weight of the 150 ppm ICGN mice was significantly lower than that of the ICGN control mice. We conclude that F significantly exacerbates renal dysfunction.
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Effects of melatonin and epiphyseal proteins on fluoride-induced adverse changes in antioxidant status of heart, liver, and kidney of rats
Several experimental and clinical reports indicated the oxidative stress-mediated adverse changes in vital organs of human and animal in fluoride (F) toxicity. Therefore, the present study was undertaken to evaluate the therapeutic effect of buffalo (Bubalus bubalis) epiphyseal (pineal) proteins (BEP) and melatonin (MEL) against F-induced oxidative stress in heart,
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Hesperidin protects liver and kidney against sodium fluoride-induced toxicity through anti-apoptotic and anti-autophagic mechanisms.
Highlights Hesperidin prevented NaF-induced hepatotoxicity and nephrotoxicity. Hesperidin attenuated NaF-induced oxidative stress and inflammation. Hesperidin reduced NaF-induced apoptosis and autophagy. Aim High dose of fluoride intake is associated with toxic effects on liver and kidney tissues. One approach to tackle these toxicities is using natural antioxidants as supplements. This study evaluated
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Fluoride exposure and kidney and liver function among adolescents in the United States: NHANES, 2013–2016.
Highlights Plasma fluoride concentrations are associated with kidney and liver parameters among United States (U.S.) adolescents Higher water fluoride concentrations are associated with lower blood urea nitrogen among U.S. adolescents Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents Altered kidney and/or liver
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Effects of melatonin and epiphyseal proteins on fluoride-induced adverse changes in antioxidant status of heart, liver, and kidney of rats
Several experimental and clinical reports indicated the oxidative stress-mediated adverse changes in vital organs of human and animal in fluoride (F) toxicity. Therefore, the present study was undertaken to evaluate the therapeutic effect of buffalo (Bubalus bubalis) epiphyseal (pineal) proteins (BEP) and melatonin (MEL) against F-induced oxidative stress in heart,
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Effect of fluoride on major organs with the different time of exposure in rats.
BACKGROUND: High fluoride levels in drinking water in relation to the prevalence of chronic kidney disease of unknown etiology (CKDu) in Sri Lanka were investigated using rats as an experimental model. METHOD: The effects of fluoride after oral administration of Sodium fluoride (NaF) at levels of 0, 0.5, 5 and 20 ppm F- were evaluated
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Fluoride Gels & Kidney Function
Scientists have found that the application of "Fluoride Gels" at the dental office causes very high spikes in the blood fluoride level. The high spikes in blood fluoride levels are a result of three factors: the high concentration of fluoride in the gel (= 12.3 mg of fluoride in each
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Fluoride as a Cause of Kidney Disease in Animals
Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing in
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Kidney: A potential target for fluoride toxicity
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Fluoride & Kidney Stones
It has long been suspected that fluoride may contribute to the formation of kidney stones. This suspicion has recently gained support from a study of an American man with skeletal fluorosis. According to the authors: "A new, important, medical problem (that seemed temporally related to cessation of fluoride exposure and subsequent negative calcium
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Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
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