Fluoride Action Network


Sperm quality, sperm hyperactivation, and the gene expression of Catsper1 were studied in adult male Kunming mice exposed to 150 mg NaF/L for 7 weeks in their drinking water. Compared with the controls, sperm quality and the proportion of hyperactivated sperm were significantly decreased in mice treated with F. Likewise, the Catsper1 gene expression level was also significantly reduced in the treatment group. On the basis of these findings, we propose that low Catsper1 gene expression in sperm may be associated with decreased sperm hyperactivation by NaF.